(12) International Application Status Report

Received at International Bureau: 15 September 2018 (15.09.2018)

Information valid as of: 15 February 2019 (15.02.2019)

Report generated on: 24 February 2020 (24.02.2020)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2019/04323407 March 2019 (07.03.2019) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/EP2018/07364303 September 2018 (03.09.2018) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
1714066.6 (GB)01 September 2017 (01.09.2017) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
C12N 15/85 (2006.01); A61K 48/00 (2006.01); C12N 5/079 (2010.01)

(71) Applicant(s):
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN [IE/IE]; College Green Dublin, Dublin 2 (IE) (for all designated states)

(72) Inventor(s):
CHADDERTON, Naomi; Department of Genetics, School of Genetics and Microbiology Trinity College Dublin, The University of Dublin College Green Dublin, Dublin 2 (IE)
FARRAR, Gwenyth Jane; Department of Genetics, School of Genetics and Microbiology Trinity College Dublin, The University of Dublin College Green Dublin, Dublin 2 (IE)
HANLON, Killian; Department of Genetics, School of Genetics and Microbiology Trinity College Dublin, The University of Dublin College Green Dublin, Dublin 2 (IE)
KENNA, Paul, F; Department of Genetics, School of Genetics and Microbiology Trinity College Dublin, The University of Dublin College Green Dublin, Dublin 2 (IE)
PALFI, Arpad; Department of Genetics, School of Genetics and Microbiology Trinity College Dublin, The University of Dublin College Green Dublin, Dublin 2 (IE)
MILLINGTON WARD, Sophia; Department of Genetics, School of Genetics and Microbiology Trinity College Dublin, The University of Dublin College Green Dublin, Dublin 2 (IE)

(74) Agent(s):
MAIN, Malcolm Charles; Murgitroyd & Company Scotland House 165-169 Scotland Street Glasgow Strathclyde G5 8PL (GB)

(54) Title (EN): RETINAL PROMOTER AND USES THEREOF
(54) Title (FR): PROMOTEUR RÉTINIEN ET SES UTILISATIONS

(57) Abstract:
(EN): Disclosed is a promoter for driving expression in the retina. The promoter sequence comprises at least NEFH promoter conserved region A and optionally one or more of NEFH conserved regions D, F, D1, K, B, C and E. Also disclosed are uses of the promoter for directing expression to retinal ganglion cells and uses for the treatment of ocular diseases.
(FR): L'invention concerne un promoteur pour actionner une expression dans la rétine. La séquence de promoteur comprend au moins une région A à promoteur de NEFH conservé et facultativement une ou plusieurs des régions D, F, D1, K, B et E à promoteur de NEFH conservé. L'invention concerne également des utilisations du promoteur pour diriger l'expression vers des cellules ganglionnaires de la rétine et des utilisations pour le traitement de maladies oculaires.

International search report:
Received at International Bureau: 19 November 2018 (19.11.2018) [EP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM

Declarations:
Declaration made as to the identity of the inventor (PCT Rules 4.17(i) and 51bis.1(a)(i))
Declaration of inventorship (Rules 4.17(iv) and 51bis.1(a)(iv)) for the purposes of the designation of the United States of America