(12) International Application Status Report

Received at International Bureau: 21 June 2017 (21.06.2017)

Information valid as of: 24 July 2017 (24.07.2017)

Report generated on: 23 April 2019 (23.04.2019)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2018/22516713 December 2018 (13.12.2018) Japanese (JA)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/JP2017/02104107 June 2017 (07.06.2017) Japanese (JA)


(51) International Patent Classification:
A61K 31/353 (2006.01); A61K 31/198 (2006.01); A61P 1/16 (2006.01); A61P 3/02 (2006.01); A61P 25/00 (2006.01); A61P 43/00 (2006.01)

(71) Applicant(s):
KAO CORPORATION [JP/JP]; 14-10, Nihonbashi Kayabacho 1-chome, Chuo-ku, Tokyo 1038210 (JP) (for all designated states)

(72) Inventor(s):
CHIN, Shu; c/o Kao Corporation Research Laboratories, 2606, Akabane, Ichikai-machi, Haga-gun, Tochigi 3213497 (JP)
OTA, Noriyasu; c/o Kao Corporation Research Laboratories, 2606, Akabane, Ichikai-machi, Haga-gun, Tochigi 3213497 (JP)
HASUMURA, Takahiro; c/o Kao Corporation Research Laboratories, 2606, Akabane, Ichikai-machi, Haga-gun, Tochigi 3213497 (JP)

(74) Agent(s):
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE; Sawanotsuru Ningyocho Bldg., 1-3-8, Nihonbashi Ningyocho, Chuo-ku, Tokyo 1030013 (JP)

(54) Title (EN): AMMONIA METABOLISM PROMOTER
(54) Title (FR): PROMOTEUR DE MÉTABOLISME D'AMMONIAC
(54) Title (JA): アンモニア代謝促進剤

(57) Abstract:
(EN): Provided are a material that promotes ammonia metabolism in the body, and a material that has an excellent ammonia metabolism ameliorative action and is effective for improving stamina and resisting fatigue. Also provided are: an ammonia metabolism promoter comprising a catechin as an active ingredient; a prophylactic or ameliorative agent for hyperammonemia, hepatic encephalopathy, or chronic fatigue syndrome, the prophylactic or ameliorative agent comprising a catechin as an active ingredient; and an ammonia metabolism promoter, a stamina improvement agent, and an anti-fatigue agent comprising a catechin, citrulline, and arginine as active ingredients.
(FR): L'invention fournit une substance qui promeut le métabolisme de l'ammoniac à l'intérieur du corps, et une substance qui présente une excellente action pour l'amélioration du métabolisme de l'ammoniac, et qui se révèle avantageuse en termes d'amélioration de l'endurance et de lutte contre la fatigue. Plus précisément, l'invention concerne un promoteur de métabolisme d'ammoniac ayant des catéchines en tant que principe actif. L'invention concerne également un agent de prévention ou d'amélioration de l'hyperammoniémie, de l'encéphalopathie hépatique ou du syndrome de fatigue chronique, ayant des catéchines en tant que principe actif. Ainsi, l'invention concerne un promoteur de métabolisme d'ammoniac, un agent d'amélioration de l'endurance et un agent de lutte contre la fatigue, ayant des catéchines, une citrulline et une arginine en tant que principes actifs.
(JA): 体内のアンモニア代謝を促進する素材、および優れたアンモニア代謝改善作用を有し、持久力向上および抗疲労に有効な素材の提供。カテキン類を有効成分とするアンモニア代謝促進剤。カテキン類を有効成分とする高アンモニア血症、肝性脳症もしくは慢性疲労症候群の予防もしくは改善剤。カテキン類、シトルリンおよびアルギニンを有効成分とするアンモニア代謝促進剤、持久力向上剤および抗疲労剤。

International search report:
Received at International Bureau: 24 July 2017 (24.07.2017) [JP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM