(12) International Application Status Report

Received at International Bureau: 02 May 2018 (02.05.2018)

Information valid as of: 08 October 2018 (08.10.2018)

Report generated on: 26 January 2020 (26.01.2020)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2018/19412425 October 2018 (25.10.2018) Japanese (JA)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/JP2018/01612619 April 2018 (19.04.2018) Japanese (JA)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
2017-083814 (JP)20 April 2017 (20.04.2017) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
C12N 15/12 (2006.01); A61K 35/42 (2015.01); A61L 27/38 (2006.01); A61P 11/00 (2006.01); A61P 43/00 (2006.01); C12N 5/071 (2010.01); C12N 5/16 (2006.01); C12N 15/63 (2006.01)

(71) Applicant(s):
KEIO UNIVERSITY [JP/JP]; 15-45, Mita 2-chome, Minato-ku, Tokyo 1088345 (JP) (for all designated states)

(72) Inventor(s):
ISHII Makoto; c/o KEIO UNIVERSITY, School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo 1608582 (JP)
BETSUYAKU Tomoko; c/o KEIO UNIVERSITY, School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo 1608582 (JP)
KO Minoru; c/o KEIO UNIVERSITY, School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo 1608582 (JP)
IEDA Masaki; c/o KEIO UNIVERSITY, School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo 1608582 (JP)
YOTSUKURA Masaya; c/o KEIO UNIVERSITY, School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo 1608582 (JP)
ASAMURA Hisao; c/o KEIO UNIVERSITY, School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo 1608582 (JP)
HEGAB Ahmed; c/o KEIO UNIVERSITY, School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo 1608582 (JP)
NAKATAKE Yuhki; c/o KEIO UNIVERSITY, School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo 1608582 (JP)
ODA Mayumi; c/o KEIO UNIVERSITY, School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo 1608582 (JP)

(74) Agent(s):
TANAI Sumio; 1-9-2, Marunouchi, Chiyoda-ku, Tokyo 1006620 (JP)

(54) Title (EN): REAGENT FOR DIFFERENTIATING SOMATIC CELLS INTO ALVEOLAR EPITHELIAL CELLS, AND USE OF SAID REAGENT
(54) Title (FR): RÉACTIF POUR DIFFÉRENCIER DES CELLULES SOMATIQUES EN CELLULES ÉPITHÉLIALES ALVÉOLAIRES, ET UTILISATION DUDIT RÉACTIF
(54) Title (JA): 体細胞から肺胞上皮細胞への分化用試薬及びその使用

(57) Abstract:
(EN): A reagent for differentiating somatic cells into alveolar epithelial cells, the reagent including an NK2 homeobox family gene expression vector and a Fox family gene expression vector.
(FR): L'invention concerne un réactif pour différencier des cellules somatiques en cellules épithéliales alvéolaires, le réactif comprenant un vecteur d'expression génique de la famille homéoboîte NK2 et un vecteur d'expression génique de la famille Fox.
(JA): NK2ホメオボックスファミリー遺伝子の発現ベクター及びFoxファミリー遺伝子の発現ベクターを含む、体細胞から肺胞上皮細胞への分化用試薬。

International search report:
Received at International Bureau: 23 July 2018 (23.07.2018) [JP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM