(12) International Application Status Report

Received at International Bureau: 12 December 2013 (12.12.2013)

Information valid as of: 06 March 2014 (06.03.2014)

Report generated on: 24 July 2019 (24.07.2019)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2014/09071019 June 2014 (19.06.2014) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/EP2013/07587609 December 2013 (09.12.2013) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
61/735,364 (US)10 December 2012 (10.12.2012) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
C07C 311/16 (2006.01); C07C 311/21 (2006.01); C07C 311/29 (2006.01); C07C 311/39 (2006.01); C07C 311/44 (2006.01); A61K 31/18 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01)

(71) Applicant(s):
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only)
GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080 (US) (US only)

(72) Inventor(s):
BODIL VAN NIEL, Monique; c/o Argenta Discovery Ltd. 8/9 Spire Green Centre Flex Meadow, Harlow Essex CM19 5TR (GB)
FAUBER, Benjamin; c/o Genentech, Inc. 1 DNA Way South San Francisco, California 94080 (US)
RENE, Olivier; c/o Genentech, Inc. 1 DNA Way South San Francisco, California 94080 (US)
WARD, Stuart; c/o Argenta Discovery Ltd. 8/9 Spire Green Centre Flex Meadow, Harlow Essex CM19 5TR (GB)

(74) Agent(s):
BERNARD, Guillaume; Grenzacherstrasse 124 4070 Basel (CH)

(54) Title (EN): BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS
(54) Title (FR): DÉRIVÉS DE SULFONAMIDE DE BENZYLE UTILISES EN TANT QUE MODULATEURS DE RORC

(57) Abstract:
(EN): Compounds of the formula Ia or Ib, or pharmaceutically acceptable salts thereof, wherein m, n, r, A, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
(FR): L'invention concerne des composés représentés par la formule Ia ou Ib, ou des sels pharmaceutiquement acceptables de ceux-ci, dans la formule,m, n, r, A, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, et R8 sont tels que définis dans la description. L'invention concerne également des procédés d'élaboration de ces composés ainsi que des méthodes consistant à utiliser ces composés pour traiter des maladies inflammatoires, telles que l'arthrite.

International search report:
Received at International Bureau: 03 March 2014 (03.03.2014) [EP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM