(12) International Application Status Report

Received at International Bureau: 17 June 2011 (17.06.2011)

Information valid as of: 19 November 2012 (19.11.2012)

Report generated on: 21 February 2019 (21.02.2019)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2011/15489515 December 2011 (15.12.2011) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/IB2011/05247507 June 2011 (07.06.2011) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
1575/CHE/2010 (IN)08 June 2010 (08.06.2010) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
C12N 15/30 (2006.01); C07K 14/44 (2006.01); A61K 31/395 (2006.01); G01N 31/00 (2006.01)

(71) Applicant(s):
INDIAN INSTITUTE OF SCIENCE [IN/IN]; Bangalore, Karnataka 560 012 (IN) (for all designated states except US)
TATU, Utpal [IN/IN]; Dept. of Biochemistry Indian Institute of Science Bangalore, Karnataka 560012 (IN) (for US only)
PALLAVI, Rani [IN/IN]; Dept. of Biochemistry Indian Institute of Science Bangalore, Karnataka 560012 (IN) (for US only)
YADAV, Suresh, Chander [IN/IN]; Veterinary Parasitology National Research Centre on Equines, Sirsa Road Hisar, Haryana 125001 (IN) (for US only)
SINGH, Raj, Kumar [IN/IN]; National Research Centre on Equines Sirsa Road Hisar, Haryana 125001 (IN) (for US only)

(72) Inventor(s):
TATU, Utpal; Dept. of Biochemistry Indian Institute of Science Bangalore, Karnataka 560012 (IN)
PALLAVI, Rani; Dept. of Biochemistry Indian Institute of Science Bangalore, Karnataka 560012 (IN)
YADAV, Suresh, Chander; Veterinary Parasitology National Research Centre on Equines, Sirsa Road Hisar, Haryana 125001 (IN)
SINGH, Raj, Kumar; National Research Centre on Equines Sirsa Road Hisar, Haryana 125001 (IN)

(74) Agent(s):
VIJAYAKRISHNAN, Sindhu; K & S Partners # 4121/B, 6th Cross, 19A Main HAL II Stage (Extension) Bangalore 560 038 (IN)

(54) Title (EN): POLYNUCLEOTIDE SEQUENCE, PROCESSES, COMPOSITION AND METHODS THEREOF
(54) Title (FR): SÉQUENCE POLYNUCLÉOTIDIQUE, PROCÉDÉS, COMPOSITION ET MÉTHODES ASSOCIÉS

(57) Abstract:
(EN): The present disclosure relates to a polynucleotide sequence coding for a protein of Trypanosoma species. The disclosure further provides processes for inhibiting said protein for treatment of protozoan infections, Malaria and Surra, by Geldanamycin and 17-AAG. The disclosure also relates to processes for identification of these inhibitions, compositions and method of treatments of said infections. Lastly, the present disclosure also relates to examining the efficacy of Hsp90 inhibitor as an anti-malarial and anti-surra agents.
(FR): La présente invention concerne une séquence polynucléotidique codant pour une protéine de l'espèce Trypanosoma. L'invention concerne en outre des procédés d'inhibition de ladite protéine pour le traitement d'infections protozoaires, la malaria et la surra, par la Geldanamycine et la 17-AAG. L'invention concerne également des procédés d'identification de ces inhibitions, des compositions et des méthodes de traitement desdites infections. Pour finir, la présente invention concerne également l'examen de l'efficacité d'un inhibiteur de Hsp90 comme agents anti-malaria et anti-surra.

International search report:
Received at International Bureau: 13 December 2011 (13.12.2011) [AU]

International Report on Patentability (IPRP) Chapter II of the PCT:
Chapter II demand received: 02 April 2012 (02.04.2012)

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, MD, RU, TJ, TM

Declarations:
Declaration made as to the identity of the inventor (PCT Rules 4.17(i) and 51bis.1(a)(i))
Declaration made as applicant's entitlement, as at the international filing date, to claim the priority of the earlier application, where the applicant is not the applicant who filed the earlier application or where the applicant's name has changed since the filing of the earlier application (Rules 4.17(iii) and 51bis.1(a)(iii))
Declaration of inventorship (Rules 4.17(iv) and 51bis.1(a)(iv)) for the purposes of the designation of the United States of America