(12) International Application Status Report

Received at International Bureau: 29 October 2010 (29.10.2010)

Information valid as of: 07 April 2011 (07.04.2011)

Report generated on: 24 October 2019 (24.10.2019)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2011/05019428 April 2011 (28.04.2011) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/US2010/05360021 October 2010 (21.10.2010) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
61/253,990 (US)22 October 2009 (22.10.2009) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
A61K 39/395 (2006.01); C12Q 1/37 (2006.01); G01N 33/53 (2006.01)

(71) Applicant(s):
GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080 (US) (AE, AG, AM, AO, AU, AZ, BA, BB, BF, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CI, CL, CM, CO, CR, CU, DM, DO, DZ, EC, EG, GA, GD, GE, GH, GM, GN, GQ, GT, GW, HN, ID, IL, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LY, MA, MD, ME, MG, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NZ, OM, PE, PG, PH, RU, SC, SD, SG, SL, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only)
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (AL, AT, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR only)
GANESAN, Rajkumar [IN/US]; c/o Genentech, Inc. 1 DNA Way South San Francisco, California 94080 (US) (for US only)
KIRCHHOFER, Daniel [US/US]; c/o Genentech, Inc. 1 DNA Way South San Francisco, California 94080 (US) (for US only)

(72) Inventor(s):
GANESAN, Rajkumar; c/o Genentech, Inc. 1 DNA Way South San Francisco, California 94080 (US)
KIRCHHOFER, Daniel; c/o Genentech, Inc. 1 DNA Way South San Francisco, California 94080 (US)

(74) Agent(s):
COBURN, Cara, M.; GENENTECH, INC. 1 DNA Way MS 49 South San Francisco, California 94080 (US)

(54) Title (EN): METHODS AND COMPOSITIONS FOR MODULATING HEPSIN ACTIVATION OF MACROPHAGE-STIMULATING PROTEIN
(54) Title (FR): PROCÉDÉS ET COMPOSITIONS POUR MODULER L'ACTIVATION D'HEPSINE D'UNE PROTÉINE DE STIMULATION DE MACROPHAGE

(57) Abstract:
(EN): The invention provides methods and compositions for modulating hepsin activity and the MSP/Ron pathway, in particular by regulating pro-MSP activation by hepsin.
(FR): L'invention concerne des procédés et compositions visant à moduler l'activité d'hepsine et le chemin MSP/Ron, en particulier en régulant l'activation pro-MSP par l'hepsine.

International search report:
Received at International Bureau: 14 March 2011 (14.03.2011) [EP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, MD, RU, TJ, TM