(12) International Application Status Report

Received at International Bureau: 01 February 2010 (01.02.2010)

Information valid as of: 07 July 2010 (07.07.2010)

Report generated on: 11 December 2019 (11.12.2019)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2010/08419929 July 2010 (29.07.2010) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/EP2010/05083326 January 2010 (26.01.2010) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
09151332.5 (EP)26 January 2009 (26.01.2009) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
A61K 9/127 (2006.01); A61K 31/198 (2006.01); A61K 47/48 (2006.01)

(71) Applicant(s):
ACADEMISCH MEDISCH CENTRUM [NL/NL]; Postbus 22700 NL-1100 DE Amsterdam (NL) (for all designated states except US)
HEGER, Michal [NL/NL]; Torenlaan 58 NL-1391 Abcoude (NL) (for US only)

(72) Inventor(s):
HEGER, Michal; Torenlaan 58 NL-1391 Abcoude (NL)

(74) Agent(s):
VAN SOMEREN, Petronella Francisca Hendrika Maria; Sweelinckplein 1 NL-2517 GK Den Haag (NL)

(54) Title (EN): DRUG DELIVERY SYSTEM FOR USE IN THE TREATMENT OF VASCULAR AND VESSEL-RELATED PATHOLOGIES
(54) Title (FR): SYSTÈME D'ADMINISTRATION DE MÉDICAMENT DESTINÉ À ÊTRE UTILISÉ DANS LE TRAITEMENT DE PATHOLOGIES VASCULAIRES ET DE PATHOLOGIES LIÉES AUX VAISSEAUX

(57) Abstract:
(EN): The present invention relates to a drug delivery system for use in the treatment of vascular and vessel-related pathologies, comprising a drug delivery platform that comprises at least one compound capable of exerting an effect on the formation and/or maintenance of a thrombus in the vessel to be treated. The platform is preferably formed by liposomes that are sterically stabilized by grafting of poly(ethylene glycol) onto the liposome surface. The liposomes may further comprise photosensitizers and targeting molecules. The liposomes may be thermosensitive. The compound is suitably tranexamic acid. The drug delivery system is preferably used for the treatment of port wine stains.
(FR): La présente invention concerne un système d'administration de médicament destiné à être utilisé dans le traitement de pathologies vasculaires et de pathologies liées aux vaisseaux. Ledit système comprend une plateforme d'administration de médicament qui comporte au moins un composé capable d'exercer un effet sur la formation et/ou la maintenance d'un thrombus dans le vaisseau devant être traité. Ladite plateforme est, de préférence, formée par des liposomes qui sont stabilisés stériquement par greffe de poly(éthylène glycol) sur la surface desdits liposomes. Ces liposomes peuvent en outre comprendre des photosensibilisateurs et des molécules de ciblage. Les liposomes peuvent être thermosensibles. Ledit composé est, de manière adaptée, un acide tranexamique. Ledit système d'administration de médicament est de préférence utilisé dans le traitement de l'angiome plan.

International search report:
Received at International Bureau: 12 April 2010 (12.04.2010) [EP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, MD, RU, TJ, TM