(12) International Application Status Report

Received at International Bureau: 08 August 2009 (08.08.2009)

Information valid as of: 22 December 2009 (22.12.2009)

Report generated on: 19 July 2019 (19.07.2019)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2010/00918321 January 2010 (21.01.2010) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/US2009/05061815 July 2009 (15.07.2009) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
61/081,058 (US)16 July 2008 (16.07.2008) Priority document received (in compliance with PCT Rule 17.1)
61/081,060 (US)16 July 2008 (16.07.2008) Priority document received (in compliance with PCT Rule 17.1)
61/081,069 (US)16 July 2008 (16.07.2008) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); A61K 31/4545 (2006.01); A61P 3/10 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 19/08 (2006.01); A61P 25/02 (2006.01); A61P 25/28 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01)

(71) Applicant(s):
BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 And Province Line Road Princeton, NJ 08543-4000 (US) (for all designated states except US)
WACKER, Dean, A. [US/US]; C/o Bristol-Myers Squibb Co. 311 Pennington-rocky Hill Road Pennington, NJ 08534 (US) (for US only)
ROSSI, Karen, A. [US/US]; C/o Bristol-Myers Squibb Co. 311 Pennington-Rocky Hill Road Pennington, NJ 08534 (US) (for US only)
WANG, Ying [CN/US]; C/o Bristol-Myers Squibb Co. 311 Pennington-Rocky Hill Road Pennington, NJ 08534 (US) (for US only)
WU, Gang [US/US]; C/o Bristol-Myers Squibb Co. 311 Pennington-Rocky Hill Road Pennington, NJ 08534 (US) (for US only)

(72) Inventor(s):
WACKER, Dean, A.; C/o Bristol-Myers Squibb Co. 311 Pennington-rocky Hill Road Pennington, NJ 08534 (US)
ROSSI, Karen, A.; C/o Bristol-Myers Squibb Co. 311 Pennington-Rocky Hill Road Pennington, NJ 08534 (US)
WANG, Ying; C/o Bristol-Myers Squibb Co. 311 Pennington-Rocky Hill Road Pennington, NJ 08534 (US)
WU, Gang; C/o Bristol-Myers Squibb Co. 311 Pennington-Rocky Hill Road Pennington, NJ 08534 (US)

(74) Agent(s):
BOGIE, Terence, J.; Bristol-Myers Squibb Comp P.O. Box 4000 Princeton, NJ 08543-4000 (US)

(54) Title (EN): PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS
(54) Title (FR): ANALOGUES DE PYRIDONE ET DE PYRIDAZONE COMME MODULATEURS DE GPR119

(57) Abstract:
(EN): Novel compounds of structure Formula (I) or an enantiomer, a diastereomer, or a pharmaceutically acceptable salt thereof, wherein Z, R1, R2, R21, T1, T2, T3 and T4 are defined herein, are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the GPR119 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.
(FR): L'invention porte sur de nouveaux composés de la Formule structurale I : [« insérer ici la structure chimique »] I ou un énantiomère, un diastéréomère ou un sel pharmaceutiquement acceptable de ceux-ci, formule dans laquelle Z, R1, R2, R21, T1, T2, T3 et T4 sont tels que définis ici, qui sont des modulateurs du récepteur GPR119 couplé à la protéine G. Les modulateurs de récepteur GPR119 couplé à la protéine G sont utiles dans le traitement, la prévention ou le ralentissement de la progression de maladies nécessitant une thérapie par le modulateur du récepteur GPR119 couplé à la protéine G. Ainsi, l'invention concerne également des compositions comprenant ces nouveaux composés et des procédés de traitement de maladies ou affections se rapportant à l'activité du récepteur GPR119 couplé à la protéine G à l'aide de l'un quelconque de ces nouveaux composés ou d'une composition comprenant l'un quelconque de ces nouveaux composés.

International search report:
Received at International Bureau: 22 October 2009 (22.10.2009) [EP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, MD, RU, TJ, TM

Declarations:
Declaration made as applicant's entitlement, as at the international filing date, to apply for and be granted a patent (Rules 4.17(ii) and 51bis.1(a)(ii)), in a case where the declaration under Rule 4.17(iv) is not appropriate
Declaration made as applicant's entitlement, as at the international filing date, to claim the priority of the earlier application, where the applicant is not the applicant who filed the earlier application or where the applicant's name has changed since the filing of the earlier application (Rules 4.17(iii) and 51bis.1(a)(iii))
Declaration of inventorship (Rules 4.17(iv) and 51bis.1(a)(iv)) for the purposes of the designation of the United States of America