(12) International Application Status Report

Received at International Bureau: 04 March 2008 (04.03.2008)

Information valid as of: 08 August 2008 (08.08.2008)

Report generated on: 11 April 2021 (11.04.2021)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2008/10010621 August 2008 (21.08.2008) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/KR2008/00090115 February 2008 (15.02.2008) Korean (KO)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
10-2007-0016352 (KR)16 February 2007 (16.02.2007) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
A61K 9/10 (2006.01)

(71) Applicant(s):
AMOREPACIFIC CORPORATION [KR/KR]; 181, 2-ga Hangang-ro, Yongsan-gu Seoul 140-777 (KR) (for all designated states except US)
PACIFIC PHARMACEUTICAL CO., LTD. [KR/KR]; #175-2, 2-ga Hangang-ro, Yongsan-gu Seoul 140-871 (KR) (for all designated states except US)
PARK, Jin Woo [KR/KR]; Gangbyeon Apt. 303-901, #1475, Gayang-dong Gangseo-gu Seoul 157-200 (KR) (for US only)
SHIN, Kwang Hyun [KR/KR]; World Merdian Apt. 101-2706, #600, Wooman-dong Paldal-gu Suwon-si, Gyeonggi-do 442-190 (KR) (for US only)
KWON, Min Jung [KR/KR]; Pacific Pharmaceutical R & D Center, #314-1 Bora-dong, Giheung-gu Yongin-si, Gyeonggi-do 446-904 (KR) (for US only)
BAE, Joon Ho [KR/KR]; Ssangyong 2-cha Apt. C-danji 218-701 Sanghyunmaeul, Sanghyun 1-dong, Suji-gu Yongin-si, Gyeonggi-do 448-522 (KR) (for US only)
JEON, Do Yong [KR/KR]; Seongwon Apt. 101-1305, Chang 4-dong, Dobong-gu Seoul 132-734 (KR) (for US only)

(72) Inventor(s):
PARK, Jin Woo; Gangbyeon Apt. 303-901, #1475, Gayang-dong Gangseo-gu Seoul 157-200 (KR)
SHIN, Kwang Hyun; World Merdian Apt. 101-2706, #600, Wooman-dong Paldal-gu Suwon-si, Gyeonggi-do 442-190 (KR)
KWON, Min Jung; Pacific Pharmaceutical R & D Center, #314-1 Bora-dong, Giheung-gu Yongin-si, Gyeonggi-do 446-904 (KR)
BAE, Joon Ho; Ssangyong 2-cha Apt. C-danji 218-701 Sanghyunmaeul, Sanghyun 1-dong, Suji-gu Yongin-si, Gyeonggi-do 448-522 (KR)
JEON, Do Yong; Seongwon Apt. 101-1305, Chang 4-dong, Dobong-gu Seoul 132-734 (KR)

(74) Agent(s):
JANG, Seongku; 19th Fl., Trust Tower, #275-7, Yangjae-dong Seocho-gu Seoul 137-130 (KR)

(54) Title (EN): CONTROLLED RELEASE PREPARATION CONTAINING CILOSTAZOLAND PROCESS FOR THE PREPARATION THEREOF
(54) Title (FR): PRÉPARATION À LIBÉRATION CONTRÔLÉE CONTENANT DU CILOSTAZOL ET SON PROCÉDÉ DE FABRICATION

(57) Abstract:
(EN): A controlled release preparation which comprises particles containing cilostazol or its pharmaceutically acceptable salt dispersed in a solubilizing agent and an erodible material encasing said particles which is capable of forming a hydrogel, can maintain a constant level of cilostazol in the blood through its slow release during its prolonged residence time in the stomach and intestines, thereby minimizing adverse effects caused by rapid release of the drug or solubilizing agent.
(FR): Préparation à libération contrôlée contenant des particules contenant elles-mêmes du cilostazol ou un sel de qualité pharmaceutique de cette susbstance, dispersée dans un agent solubilisant et une matière érodable renfermant lesdites particules. Cette préparation peut former un hydrogel et maintenir un niveau constant de cilostazol dans le sang grâce à sa libération lente pendant un temps de séjour prolongé dans l'estomac et les intestins, ce qui atténue les effets contraires dus à une libération rapide du médicament ou de l'agent solubilisant.

International search report:
Received at International Bureau: 07 May 2008 (07.05.2008) [KR]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, MD, RU, TJ, TM