(12) International Application Status Report

Received at International Bureau: 11 May 2006 (11.05.2006)

Information valid as of: Not available

Report generated on: 19 July 2019 (19.07.2019)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2006/08522817 August 2006 (17.08.2006) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/IB2006/00122713 January 2006 (13.01.2006) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
60/644,360 (US)14 January 2005 (14.01.2005) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
A61K 31/7052 (2006.01); A61P 33/06 (2006.01); C07H 17/08 (2006.01)

(71) Applicant(s):
GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. [HR/HR]; Prilaz baruna Filipovica 29 Zagreb 10000 (HR) (for all designated states except US)
BUKVIC KRAJACIC, Mirjana [HR/HR]; Tijardoviceva 28 Zagreb 10000 (HR) (for US only)
KUJUNDZIC, Nedjeljko [HR/HR]; Slavenskog 4 Zagreb 10000 (HR) (for US only)
IVEZIC, Zrinka [HR/HR]; Karl Schwedgasse 98 A-1230 Vienna (HR) (for US only)
ALIHODZIC, Sulejman [HR/HR]; Brazilska 10 Za reb 10090 (HR) (for US only)
HUTINEC, Antun [HR/HR]; Kupreska 6 Zagreb 10040 (HR) (for US only)
FAJDETIC, Andrea [HR/HR]; Ante Topic Mimare 28 Zagreb 10000 (HR) (for US only)

(72) Inventor(s):
BUKVIC KRAJACIC, Mirjana; Tijardoviceva 28 Zagreb 10000 (HR)
KUJUNDZIC, Nedjeljko; Slavenskog 4 Zagreb 10000 (HR)
IVEZIC, Zrinka; Karl Schwedgasse 98 A-1230 Vienna (HR)
ALIHODZIC, Sulejman; Brazilska 10 Za reb 10090 (HR)
HUTINEC, Antun; Kupreska 6 Zagreb 10040 (HR)
FAJDETIC, Andrea; Ante Topic Mimare 28 Zagreb 10000 (HR)


(54) Title (EN): 9A-CARBAMOYL-Y-AMINOPROPYL AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY
(54) Title (FR): NOUVEAUX AZALIDES 9A-CARBAMOYL-AMINOALKYLE ET 9A-THIOCARBAMOYLE-AMINOALKYLE ANTIPALUDEENS

(57) Abstract:
(EN): Novel 9a-N'-substituted-carbamoyl- and tMocarbamoyl-aminoalkyl-9a-aza-9-deoxo- 9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro- 9a-homoerythromycin A compounds having antimalarial activity are claimed. More particularly, the invention relates to 9a-N'-substituted-carbamoyl- and thiocarbamoyl- ß-aminoethyl- or -γ-aminopropyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A compounds and to pharmaceutically acceptable derivatives thereof having antimalarial activity.
(FR): La présente invention concerne des nouveaux composés -N'-substitués-carbamoyl- et tMocarbamoyl-aminoalkyl-9a~aza-9-déoxo- 9-dihydro-9a-homoérythromycine A et 3~0-décladinosyl-9a-aza-9-déoxo-9-dihydro- 9a-homoérythromycine A possédant une activité antiplaludéenne. Cette invention concerne plus particulièrement des composés 9a-N'-substitués-carbamoyl- et thiocarbamoy- ß-aminoéthyl- ou -?-aminopropyl-9a-aza-9-déoxo-9-dihydro-9a-homoérythromycine A et 3-O-décladinosyl-9a-aza-9-déoxo-9-dihydro-9a-homoérythromycine A et des dérivés de ceux-ci répondant aux normes pharmaceutiques possédant une activité antipaludéenne.

International search report:
Received at International Bureau: 16 October 2006 (16.10.2006) [EP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
European Patent Office (EPO) : AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, MD, RU, TJ, TM

Declarations:
Declaration of inventorship (Rules 4.17(iv) and 51bis.1(a)(iv)) for the purposes of the designation of the United States of America