(12) International Application Status Report

Received at International Bureau: 12 November 2001 (12.11.2001)

Information valid as of: Not available

Report generated on: 19 September 2021 (19.09.2021)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2002/02258621 March 2002 (21.03.2002) German (DE)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/EP2001/01020405 September 2001 (05.09.2001) German (DE)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
100 46 029.1 (DE)18 September 2000 (18.09.2000) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
A61K 45/06 (2006.01); C07D 231/56 (2006.01)

(71) Applicant(s):
BAYER AKTIENGESELLSCHAFT [DE/DE]; 51368 Leverkusen (DE) (for all designated states except US)
WOLTERING, Michael [DE/DE]; Falkenberg 151 42113 Wuppertal (DE) (for US only)
HANING, Helmut [DE/DE]; Claudiusweg 3 42115 Wuppertal (DE) (for US only)
SCHMIDT, Gunter [DE/DE]; Pahlkestr. 63 42115 Wuppertal (DE) (for US only)
PERNERSTORFER, Josef [AT/DE]; Alsenstr. 19 A-42103 Wuppertal (AT) (for US only)
BISCHOFF, Hilmar [DE/DE]; Am Rohm 78 42113 Wuppertal (DE) (for US only)
KRETSCHMER, Axel [DE/DE]; Am Acker 23 42113 Wuppertal (DE) (for US only)
VÖHRINGER, Verena [DE/DE]; Am Hochsitz 17 42113 Wuppertal (DE) (for US only)
FAESTE, Christiane [DE/DE]; Zwirnerweg 15 42781 Haan (DE) (for US only)

(72) Inventor(s):
WOLTERING, Michael; Falkenberg 151 42113 Wuppertal (DE)
HANING, Helmut; Claudiusweg 3 42115 Wuppertal (DE)
SCHMIDT, Gunter; Pahlkestr. 63 42115 Wuppertal (DE)
PERNERSTORFER, Josef; Alsenstr. 19 A-42103 Wuppertal (AT)
BISCHOFF, Hilmar; Am Rohm 78 42113 Wuppertal (DE)
KRETSCHMER, Axel; Am Acker 23 42113 Wuppertal (DE)
VÖHRINGER, Verena; Am Hochsitz 17 42113 Wuppertal (DE)
FAESTE, Christiane; Zwirnerweg 15 42781 Haan (DE)

(74) Common Representative(s):
BAYER AKTIENGESELLSCHAFT; 51368 Leverkusen (DE)

(54) Title (EN): INDAZOLES HAVING AN ACTION SIMILAR TO THAT OF A THYROID HORMONE, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE IN MEDICAMENTS
(54) Title (FR): INDAZOLES A ACTION ANALOGUE A L'HORMONE THYROIDIENNE, LEUR PROCEDE DE FABRICATION ET LEUR UTILISATION DANS DES MEDICAMENTS
(54) Title (DE): INDAZOLE MIT THYROID-HORMON-ÄHNLICHER WIRKUNG, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG IN ARZNEIMITTELN

(57) Abstract:
(EN): The invention relates to novel indazole derivatives of formula (I), in which Z represents O, S, CH2, CHF or CF2, and wherein R1-R7 have meanings as cited in Claim No. 1. The inventive indazole derivatives have an action similar to that of a thyroid hormone. The invention also relates to a method for producing said indazole derivatives, and to their use in medicaments.
(FR): L'invention concerne de nouveaux dérivés de l'indazole, de formule (I), dans laquelle, Z désigne O, S, CH2, CHF ou CF2, et où R1-R7 ont les significations spécifiées dans la revendication 1, ces dérivés ayant une action analogue à l'hormone thyroïdienne. L'invention concerne en outre leur procédé de fabrication et leur utilisation dans des médicaments.
(DE): Die Erfindung betrifft neue Indazolderivate der Formel (I), in welcher Z für O, S, CH2, CHF oder CF2 steht, und worin R1-R7 die in Anspruch 1 genannte Bedeutung haben, mit Thyroid-Hormon-ähnlicher Wirkung, Verfahren zur ihrer Herstellung sowie ihre Verwendung in Arzneimitteln.

International search report:
Received at International Bureau: 07 February 2002 (07.02.2002) [EP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Chapter II demand received: 14 March 2002 (14.03.2002)

(81) Designated States:
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
European Patent Office (EPO) : AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, MD, RU, TJ, TM