(12) International Application Status Report

Received at International Bureau: 04 May 2001 (04.05.2001)

Information valid as of: Not available

Report generated on: 28 January 2021 (28.01.2021)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2001/07707918 October 2001 (18.10.2001) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/US2001/01101404 April 2001 (04.04.2001) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
60/194,851 (US)05 April 2000 (05.04.2000)
60/252,031 (US)20 November 2000 (20.11.2000)

(51) International Patent Classification:
C07D 213/74 (2006.01)

(71) Applicant(s):
PHARMACIA CORPORATION [US/US]; Corporate Patent Department P.O. Box 5110 Chicago, IL 60680 (US) (for all designated states except US)
SOUTH, Michael, S. [US/US]; 11671 Chieftain Drive St. Louis, MO 63146 (US) (for US only)
MA, Chun, C. [US/US]; 2056 Winterhaven Court Chesterfield, MO 63017 (US) (for US only)
KOELLER, Kevin, J. [US/US]; 11929 Glenridge Dr. Maryland Heights, MO 60343 (US) (for US only)
RAHMAN, Hayat, K. [US/US]; 540 Big Bend Belleville, IL 62226 (US) (for US only)
NEUMANN, William, L. [US/US]; 212 West Monroe St. Louis, MO 63122 (US) (for US only)

(72) Inventor(s):
SOUTH, Michael, S.; 11671 Chieftain Drive St. Louis, MO 63146 (US)
MA, Chun, C.; 2056 Winterhaven Court Chesterfield, MO 63017 (US)
KOELLER, Kevin, J.; 11929 Glenridge Dr. Maryland Heights, MO 60343 (US)
RAHMAN, Hayat, K.; 540 Big Bend Belleville, IL 62226 (US)
NEUMANN, William, L.; 212 West Monroe St. Louis, MO 63122 (US)

(74) Agent(s):
HEJLEK, Edward, J.; Senniger, Powers, Leavitt & Roedel One Metropolitan Square, 16th Floor St. Louis, MO 63102 (US)

(54) Title (EN): POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRIDONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE
(54) Title (FR): PYRIDONES POLYCYCLIQUES 4-ARYL ET HETEROARYL SUBSTITUEES UTILES POUR L'INHIBITION SELECTIVE DE LA CASCADE DE COAGULATION

(57) Abstract:
(EN): The invention relates to polycyclic aryl and heteroaryl substituted 4-pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
(FR): La présente invention concerne des composés polycycliques de pyridone 4-aryl et hétéroaryl qui sont utiles en tant qu'inhibiteurs des sérine protéases de la cascade de coagulation et des composés, des compositions et des procédés destinés à l'anticoagulothérapie utilisée pour traiter et prévenir divers états thrombotiques y compris les maladies des artères coronaires et les maladies cérébrovasculaires.

International search report:
Received at International Bureau: 21 November 2001 (21.11.2001) [EP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Chapter II demand received: 16 October 2001 (16.10.2001)

(81) Designated States:
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
European Patent Office (EPO) : AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, MD, RU, TJ, TM