(12) International Application Status Report

Received at International Bureau: 31 October 2000 (31.10.2000)

Information valid as of: Not available

Report generated on: 16 January 2021 (16.01.2021)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2001/07231904 October 2001 (04.10.2001) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/US2000/02708702 October 2000 (02.10.2000) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
09/537,211 (US)29 March 2000 (29.03.2000) Priority document received (in compliance with PCT Rule 17.1)
09/640,768 (US)17 August 2000 (17.08.2000) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
A61K 36/00 (2006.01)

(71) Applicant(s):
PURDUE RESEARCH FOUNDATION [US/US]; Purdue University 1063 Hovde Hall West Lafayette, IN 47907-1063 (US) (for all designated states)
PHARMANEX, INC. [US/US]; Suite 701, 2000 Sierra Point Parkway Brisbane, CA 94005-1935 (US) (for all designated states)

(72) Inventor(s):
MORRE, Dorothy, M.; 1112 Cherry Lane West Lafayette, IN 47906 (US)
MORRE, D., James; 1112 Cherry Lane West Lafayette, IN 47906 (US)
COOPER, Raymond; 476 Sylvan Avenue Mountain View, CA 94041 (US)
SUN, Howard; 780 Pradera Way San Ramon, CA 94583 (US)
YE, Qing; 118 Bao Lin Yi Cun, #503 Shanghai 201900 (CN)

(74) Agent(s):
CORUZZI, Laura, A.; Pennie & Edmonds LLP 1155 Avenue of the Americas New York, NY 10036 (US)

(54) Title (EN): TEA CATECHIN FORMULATIONS AND PROCESSES FOR MAKING SAME
(54) Title (FR): FORMULATIONS DE CATECHINES DU THE ET PROCEDES DE FABRICATION ASSOCIES

(57) Abstract:
(EN): The invention described herein encompasses methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins with reduced levels of EGCg, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds.
(FR): L'invention concerne une méthode et des compositions permettant de traiter le cancer ou des tumeurs solides et consistant à administrer une quantité thérapeutiquement efficace de catéchines, un groupe de polyphénols issus du thé vert, à un mammifère nécessitant un tel traitement. Ces compositions de catéchines comprennent notamment, l'épigallocatéchine gallate (EGCg), l'épicatéchine (EC), l'épicatéchine gallate (ECG), l'épigallocatéchine (EGC). Les compositions uniques selon l'invention contiennent différentes combinaisons de catéchines, seules ou combinées les unes avec les autres, ou d'autres agents thérapeutiques et permettent de traiter des cancers primaires et métastatiques chez les humains. L'invention concerne également les différents modes d'administration de ces composés thérapeutiques.

International search report:
Received at International Bureau: 06 March 2001 (06.03.2001) [EP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Chapter II demand received: 10 October 2001 (10.10.2001)

(81) Designated States:
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW
European Patent Office (EPO) : AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, MD, RU, TJ, TM