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1. (WO2019050504) MASS SPECTROMETRY DISTINGUISHABLE SYNTHETIC COMPOUNDS, LIBRARIES, AND METHODS THEREOF
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What is Claimed is;

1. A method comprising,

using logic circuitry to:

select a plurality of molecules that include a plurality of subgroups, each of the plurality of molecules exhibiting a mass spectrometry characteristic that is distinguishable from mass spectrometry characteristics of other molecules of the plurality;

assign the plurality of molecules with a position in a sequence of a plurality of synthetic compounds forming a library; and

define, as data in a memory circuit of the logic circuitry, the plurality of synthetic compounds that are sequenceable via mass spectrometry using the assigned positions of the plurality of molecules for communicating to other circuitry for formation thereof via coupling chemistry or screening of a particular function.

2. The method of claim 1 , wherein selecting the plurality of molecules includes (1) using the logic circuitry to design molecules and (2) selecting a subset of the molecules that exhibit mass spectrometry characteristics separable from each other by a threshold value.

3. The method of claim 1, further including correlating the plurality of molecules with the assigned position in the sequence of the plurality of synthetic compounds, wherein each position in the sequence of the plurality of synthetic compounds includes a set of possible molecules among the plurality of molecules.

4. The method of claim 1 , further including selecting, using the logic circuitry configured and arranged with the memory circuit, the plurality of molecules by:

selecting the plurality of subgroups that exhibit a mass spectrometry characteristic that is distinguishable from other subgroups in the plurality;

correlating, as data in the memory circuit, each of the plurality of subgroups with the assigned position in a sequence of prospective molecules used for forming the plurality of synthetic compounds; and

selecting the plurality of molecules among the prospective molecules that exhibit the mass spectrometry characteristics that are distinguishable by a threshold value from other mass spectrometry characteristics.

5. The method of claim 4, wherein correlating each of the plurality of subgroups with the position in the sequence includes selecting, using the logic circuitry, a set of subgroups among the plurality of subgroups for each position.

6. The method of claim 1 , further including communicating, using the logic circuitry, the defined plurality of synthetic compounds as a data object and the plurality of molecules with the assigned positions in the sequence of the plurality of synthetic compounds to the other circuitry for formation thereof via coupling chemistry or screening for the particular function.

7. The method of claim 1, further including performing mass spectrometry on the plurality of molecules to generate a reference pattern used for error control and storing the reference partem via the memory circuit, wherein the mass spectrometry characteristic includes a property selected from the group consisting of: molecular weight, fragmentation pattern, isotope distribution, and a combination thereof.

8. The method of claim 1 , further including forming the plurality of synthetic compounds via coupling chemistry, where each of the plurality of synthetic compounds includes a different sequence of a subset of the plurality of molecules with cleavable groups between at least some molecules in the subset.

9. The method of claim 8, further including screening the plurality of synthetic compounds for a particular physical function and selecting a synthetic compound among the plurality of synthetic compounds that exhibits the particular function.

10. The method of claim 9, further including forming the selected synthetic compound, or a conjugate form thereof, that exhibits the particular function.

1 1. A library of synthetic compounds used for screening of a particular function, the library comprising:

a plurality of synthetic compounds that include different sequential combinations of a plurality of molecules, each of the plurality of molecules exhibiting a mass spectrometry characteristic this is distinguishable from other molecules of the plurality, and wherein each compound includes:

a subset of the plurality of molecules in a sequence, and cleavable groups positioned between at least some of the subset of the plurality of molecules.

12. The library of synthetic compounds of claim 11 , wherein the plurality of molecules include different subgroups that exhibit functional characteristics.

13. The library of synthetic compounds of claim 12, wherein each of the different subgroups exhibit a mass spectrometry characteristic this is distinguishable from the other subgroups, and each of the different subgroups is assigned a position in the sequence of the plurality of molecules.

14. The library of synthetic compounds of claim 11 , wherein each of the plurality of molecules is associated a position in the sequence of each of the plurality of synthetic compounds.

15. The library of synthetic compounds of claim 11 , wherein the plurality of molecules exhibit the mass spectrometry characteristics that are distinguishable from one another by a threshold value.

16. The library of synthetic compounds of claim 1 1, wherein each of the plurality of compounds are configured and arranged to identify a sequence of the synthetic compounds via the mass spectrometry characteristics of the subset of the plurality of molecules respectively forming the synthetic compounds.

17. The library of synthetic compounds of claim 11 , wherein each of the plurality of compounds are configured and arranged to be sequenced via mass spectrometry with a detection sensitivity.

18. A method comprising:

generating an assay using a library of synthetic compounds and a target, the library including:

a plurality of synthetic compounds that include different sequential combinations of a plurality of molecules, each of the synthetic compounds attached to a polymer bead and each of the plurality of molecules exhibiting a mass spectrometry characteristic that is distinguishable from other molecules of the plurality, and wherein each synthetic compound includes:

a subset of the plurality of molecules in a sequential, and

cleavable groups positioned between at least some of the subset of the plurality of molecules;

screening the assay for a synthetic compound among the plurality of synthetic compounds that exhibits a particular function and isolating the synthetic compound;

separating both the synthetic compound from the polymer bead and the respective subset of molecules in the subset forming the synthetic compound from one another; and sequencing the synthetic compound by identifying the mass spectrometry characteristics of the subset of molecules via mass spectrometry.

19. The method of claim 18, wherein sequencing the synthetic compound includes comparing the identified mass spectrometry characteristics to known mass spectrometry characteristics of the plurality of molecules.

20. The method of claim 18, wherein sequencing the synthetic compound includes comparing the identified mass spectrometry characteristics to known mass spectrometry characteristics of the plurality of molecules that are associated with known positions of the plurality of molecules in a sequence order of compounds in the library.