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1. (WO2019030007) PROCESS FOR THE RECOVERY OF FERMENTATION PRODUCTS
Anmerkung: Text basiert auf automatischer optischer Zeichenerkennung (OCR). Verwenden Sie bitte aus rechtlichen Gründen die PDF-Version.

CLAIMS

1 . A method for the recovery of one or more fermentation products with a solubility in water lower than 1 g/L from a fermentation medium comprising the following steps:

(a) optionally concentrating the fermentation medium or a cellular fraction thereof by removal of free solvent;

(b) drying the fermentation medium or a cellular fraction thereof or the concentrate obtained in step (a), thereby generating a gaseous phase; and

(c) recovering the one or more fermentation products from the gaseous phase obtained in step (b).

2. The method of according to claim 1 , wherein the one or more fermentation products are hydrocarbons, fatty acids or polyalkanoates.

3. The method according to claim 1 or 2, wherein the one or more fermentation products are hydrocarbons, preferably terpenes, more preferably sesquiterpenes.

4. The method according to claim 3, wherein the fermentation product is farnesene.

5. The method according to any one of claims 1 to 4, wherein the one or more fermentation products are cell-associated fermentation products.

6. The method according to any one of claims 1 to 5, wherein said concentrate contains less than 3 wt% (v/v) free solvent, preferably less than 1 wt% (v/v) free solvent.

7. The method according to any one of claims 1 to 6, wherein the concentration step (a) is performed using a decanter centrifuge.

8. The method according to any one of claims 1 to 7, wherein step (b) is performed using a combination of contact and fluidized bed drying.

9. The method according to any one of claims 1 to 8, wherein step (c) is performed by condensing the gaseous phase and separating the one or more fermentation products from the condensate.

10. The method according to claim 9, wherein said separation of the one or more fermentation products from the condensate is performed by decanting the condensate.

1 1 . The method according to any one of claims 1 to 10, wherein said cellular fraction is obtained following solid/liquid separation of the fermentation mixture into a solid/liquid heavy phase and a solid/liquid light phase, wherein said solid/liquid heavy phase comprises the cellular fraction.

12. The method according to claim 1 1 , wherein said solid/liquid separation is performed by means of a centrifuge.

13. The method according to any one of claims 1 1 or 12, further comprising recovering said one or more fermentation products from the solid/liquid light phase.

14. The method according to claim 13, wherein said one or more fermentation products are recovered from the solid/liquid light phase by the following steps:

optionally clarifying the solid/liquid light phase,

concentrating the solid/liquid light phase or the clarified solid/liquid light phase to form a concentrated solid/liquid light phase,

- evaporating the concentrated solid/liquid light phase in a first evaporation,

evaporating the residual concentrated solid/liquid light phase from the first evaporation in a second evaporation,

recovering the one or more fermentation products from the gaseous phase from the second evaporation, and

- optionally recovering said one or more fermentation products from the gaseous phase from the first evaporation.

15. The method according to claim 14, wherein the residual concentrated solid/liquid light phase from the second evaporation is subjected to the drying step (b).

16. The method according to claim 14 or 15, wherein the solid/liquid light phase or the clarified solid/liquid light phase is concentrated by means of one or more membranes, preferably ceramic membranes.

17. A method for the recovery of one or more fermentation products from a fermentation medium comprising the following steps:

optionally separating the fermentation medium into a solid/liquid heavy phase and a solid/liquid light phase,

- optionally clarifying the fermentation medium or the solid/liquid light phase,

concentrating the fermentation medium, the solid/liquid light phase, the clarified fermentation medium or the clarified solid/liquid light phase into a concentrate and a permeate,

evaporating the concentrate in a first evaporation,

- evaporating the residual concentrate in the first evaporation in a second evaporation,

recovering the one or more fermentation products from the gaseous phase from the second evaporation, and

optionally recovering the one or more fermentation products from the gaseous phase from the first evaporation;

wherein said concentration step is performed by means of one or more membranes, wherein said membrane is permeable for the fermentation medium.

18. A method for the production of an organic compound, comprising the following steps:

(i) providing a genetically engineered micro-organism capable of producing the organic compound;

(ii) fermenting a fermentable medium using said micro-organism; and

(iii) recovering the fermentation product from the fermentation mixture by a method according to any one of claims 1 to 17.