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1. (WO2018197621) SALMONELLA AND IMMUNOGENIC COMPOSITION CONTAINING THE SAME AS WELL AS ITS USE

Pub. No.:    WO/2018/197621    International Application No.:    PCT/EP2018/060747
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Fri Apr 27 01:59:59 CEST 2018
IPC: C07K 14/255
C12N 15/52
C12N 1/36
A61K 38/16
Applicants: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
Inventors: ERHARDT, Marc
FELGNER, Sebastian
KOCIJANCIC, Dino
WEISS, Siegfried
Title: SALMONELLA AND IMMUNOGENIC COMPOSITION CONTAINING THE SAME AS WELL AS ITS USE
Abstract:
- 34 - Abstract In a first aspect, the present invention relates to a mutated Salmonella strain com- prising mutations in flagellin II genes, like the fliF gene, in particular, in addition the aroA gene, the lpxR gene, the pagP gene, the pagL gene, the ydiV gene and option-5 ally the eptA gene and further optionally, the arnT gene. In a further aspect, immuno- genic compositions comprising said Salmonella strain are provided optionally to- gether with a pharmaceutically accepted carrier, diluent or effluent. Moreover, a method for producing outer membrane vesicles of Salmonella is provided, said method comprises the steps of cultivating the Salmonella strain according to the pre-10 sent invention and isolating the outer membrane vesicles accordingly. The present invention provides the bacteria or the outer membrane vesicles (OMVs) obtainable by the methods according to the present invention and its use as a transport moiety or as an immunogenic composition, like a vaccine or immunotherapy platform espe- cially for therapeutic treatment of cancer of tissue or blood. 15