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1. (WO2018177899) NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS

Pub. No.:    WO/2018/177899    International Application No.:    PCT/EP2018/057359
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Fri Mar 23 00:59:59 CET 2018
IPC: C07D 401/12
C07D 239/30
C07D 498/04
A61K 31/519
A61P 9/00
A61P 35/00
Applicants: BAYER AKTIENGESELLSCHAFT
BAYER PHARMA AKTIENGESELLSCHAFT
Inventors: LÜCKING, Ulrich
HOG, Daniel
CHRIST, Clara
SACK, Ulrike
SIEGEL, Franziska
LIENAU, Philip
WERBECK, Nicolas
Title: NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS
Abstract:
BHC173002FC -192- A b s t r a c t The present invention relates to novel modified macrocyclic compounds with improved tolerability of 5 general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I). 10