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1. (WO2017140803) MODULATORS OF TUMOR IMMUNE RESISTANCE FOR THE TREATMENT OF CANCER

Pub. No.:    WO/2017/140803    International Application No.:    PCT/EP2017/053540
Publication Date: Fri Aug 25 01:59:59 CEST 2017 International Filing Date: Fri Feb 17 00:59:59 CET 2017
IPC: A61K 31/4375
A61K 31/517
A61K 31/713
A61K 39/00
A61K 45/06
G01N 33/50
Applicants: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS
Inventors: KHANDELWAL, Nisit
BECKHOVE, Philipp
BOUTROS, Michael
BREINIG, Marco
MICHELS, Tillmann
Title: MODULATORS OF TUMOR IMMUNE RESISTANCE FOR THE TREATMENT OF CANCER
Abstract:
The present invention pertains to novel modulators of tumor resistance against T-cell mediated cytotoxic immune responses. The invention provides antagonists of tumor immune escape mechanisms and methods and other aspects related thereto, and therefore provides novel approaches for treating or aiding a treatment of various cancerous diseases and/or the diagnosis thereof. The invention pertains to both negative and positive regulators of tumor cell resistance and suggests the use inhibitors or activators of these genes for therapeutic purposes. Inparticular aspects, the invention provides combination therapeutics and/or therapies involving such inhibitors or activators. The invention furthermore provides screening methods for novel cancer therapeutics modulating the action of the identified genes,diagnostic approaches to detect cancer resistance to cytotoxic T-cells as well as pharmaceutical compositions and diagnostic kits, for use with or related to for performing these methods.