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1. (WO2017125443) SYSTEM AND METHOD FOR THE DETERMINATION OF A DOSE IN RADIOTHERAPY
Anmerkung: Text basiert auf automatischer optischer Zeichenerkennung (OCR). Verwenden Sie bitte aus rechtlichen Gründen die PDF-Version.

Claims

Method for determining a dose in real time during therapy with a therapeutic substance, which comprises a therapeutic radionuclide or is radioactively labelled, by using a nuclear imaging system (12) with a nuclear detector (10, 10a, 11, 13), comprising:

providing a 3D image (15) comprising at least a region of a body (1) to be treated (22); identifying, in the 3D image (15), at least one target area (24) to be treated, and defining a region of interest (26) which includes the at least one target area (24);

registering the position of the nuclear detector (10, 10a, 11, 13) with regard to the 3D image (15);

positioning the nuclear detector (10, 10a, 11, 13) to detect radiation from a region of interest (26) to which the therapeutic substance has been applied, and detecting radiation;

quantifying in real time an actual target dose present in the target area (24), by evaluating the detected radiation,

outputting information about the actual target dose;

wherein the quantifying includes taking into account at least one of: previous simulations with known simulated radiation distributions, previous measurements on known radiation distributions, and the radiation of a reference radiation source (40).

The method of claim 1, further comprising:

determining whether the actual target dose has reached at least one of: a predefined upper threshold Su, and a predefined lower threshold SL.

The method of claims 1 or 2, further comprising determining a difference d between the applied radiation activity and the actual target activity, and preferably putting out a signal related to the difference, and/or if it has reached a predetermined threshold.

The method of claims 1 to 3, wherein the nuclear imaging system (12) is adapted to detect Bremsstrahlung caused in the body (1) by the therapeutic substance.

The method of claims 1 to 4, wherein the nuclear detector (10, 10a, 11, 13) comprises:

a. a 2D Gamma camera (11) or a Gamma probe (10a); or

b. a grid (13) of Gamma detectors, positioned adjacent to a surface of the body (1).

6. The method of claims 1 to 5, wherein pre-calculated simulations of detection values for a plurality of radiation distributions are provided in a first database (45), and wherein the actual target dose is calculated by comparing the simulations and the detected radiation.

7. The method of claims 1 to 6, wherein a second database (50) comprises measured radiation detection values for a variety of nuclear radiation distributions in a physical body phantom, and wherein the content of the second database (50) is used as input for a computation of the actual target dose.

8. The method of claim 1 to 4, wherein the nuclear detector (10, 10a, 11, 13) is adapted to be moved about the region of interest (26) during the detection of radiation.

9. The method of claim 8, wherein detected radiation from a reference radiation source (40) provided in the region of interest is used in quantifying the actual target dose.

10. A system for determining a dose during therapy with a therapeutic substance, which

comprises a therapeutic radionuclide or is radioactively labelled, the system comprising:

a nuclear imaging system (12), comprising a nuclear detector (10, 10a, 11, 13) and a control unit (14), comprising a registration module (60) for registering the nuclear detector (10) with respect to a provided 3D image (15) comprising at least a region of interest (26);

a dose evaluation module (65) for quantifying an actual target dose in a target area (24) to be treated, by evaluating data from the nuclear detector (10);

wherein quantifying in real time comprises taking into account at least one of:

previous simulations with known simulated radiation distributions, previous measurements on known radiation distributions, and the radiation of a reference radiation source (40).

11. The system of claim 10, adapted to determine whether the actual target dose has reached at least one of: a predefined upper threshold Su, and a predefined lower threshold SL.

12. The system of claims 10 or 11, wherein the dose evaluation module (65) is adapted to determine a difference between the applied radiation activity and the actual target activity, and preferably for outputting a signal related to the difference, and/or if the difference has reached a predetermined threshold.

13. The system of claims 10 to 12, wherein the nuclear imaging system (12) is adapted to detect Bremsstrahlung caused in the body (1) by a therapeutic substance.

14. The system of claims 10 to 13, wherein the nuclear detector (10, 10a, 11, 13) comprises: a. a 2D Gamma camera (11) or a Gamma probe (10a); or

b. a grid (13) of Gamma detectors, adapted to be positioned adjacent to a surface of the body (1).

15. The system of claim 14, comprising a first database (45) with pre-calculated simulations of detection values for a plurality of radiation distributions, and wherein the dose evaluation module (65) is adapted for quantifying the actual target dose on the basis of the detected radiation and the pre-calculated simulations.

16. The system of claims 10 to 15, further comprising a second database (50) comprising

measured radiation detection values for a variety of nuclear radiation distributions in a physical body phantom, and wherein the dose evaluation module is adapted for quantifying the actual target dose on the basis of the detected radiation and the measured radiation detection values.

17. The system of claims 10 to 16, wherein the nuclear detector (10) is adapted to be moved about the region of interest (26) during the detection of radiation.

18. The system of claim 17, further comprising a reference radiation source (40), wherein the dose evaluation module (65) employs detected radiation from the reference radiation source (40) in quantifying the actual target dose.