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1. (WO2016191332) METHODS, SYSTEMS, AND COMPOSITIONS FOR DETERMINING BLOOD CLOT FORMATION, AND USES THEREOF

Pub. No.:    WO/2016/191332    International Application No.:    PCT/US2016/033686
Publication Date: Fri Dec 02 00:59:59 CET 2016 International Filing Date: Mon May 23 01:59:59 CEST 2016
IPC: C12Q 1/56
C12N 5/078
C12Q 1/00
A61K 35/19
G01N 33/48
G06F 19/12
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
THE CHILDREN'S MEDICAL CENTER CORPORATION
Inventors: INGBER, Donald, E.
JAIN, Abhishek
VAN DER MEER, Andries, D.
MICHELSON, Alan, David
FRELINGER, III, Andrew, L.
BARRILE, Riccardo
Title: METHODS, SYSTEMS, AND COMPOSITIONS FOR DETERMINING BLOOD CLOT FORMATION, AND USES THEREOF
Abstract:
A method is directed to determining a thrombosis function and includes flowing a fluid sample over a surface having a fixed endothelial cell monolayer. The method further includes stimulating the fixed endothelial cell monolayer to induce formation of a clot, the clot being formed via interaction between the fixed endothelial cell monolayer and the fluid sample. In response to the clot formation, the method further includes determining a thrombosis function associated with the fluid sample and the fixed endothelial cell monolayer.