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1. (WO2015177326) 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2015/061350 P05792-WO-1
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
22 May 2015 23 May 2014
Applicant
F. HOFFMANN-LA ROCHE AG
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing filed or furnished:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS

5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.

Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein. Claimed uses are the treatment of inflammation and asthma.


6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07D 487/04 (2006.01)i; A61K 31/519 (2006.01)i; A61P 11/06 (2006.01)i; A61P 29/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07D
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2011003065 A2 (GENENTECH INC [US]; GIBBONS PAUL [US]; HANAN EMILY [US]; LIU WENDY [US) 06 January 2011 (2011-01-06)
1-35
cited in the application
claims 3, 11; examples 18, 124,460
(2)
A
WO 2012129258 A1 (MERCK SHARP & DOHME [US]; MCELROY WILLIAM T [US]; LI GUOQING [US]; HO) 27 September 2012 (2012-09-27)
1-35
page 1, line 6 - line 9; claim 1
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2011003065 A2
06 January 2011
AU 2010266188 A1
CA 2767097 A1
CN 102482284 A
CO 6491081 A2
CR 20120053 A
EC SP12011645 A
EP 2448941 A2
JP 2012532112 A
KR 20120097473 A
MA 33502 B1
PE 05752012 A1
RU 2012103487 A
SG 177454 A1
US 2012190665 A1
US 2015152117 A1
WO 2011003065 A2
02 February 2012
06 January 2011
30 May 2012
31 July 2012
21 May 2012
30 March 2012
09 May 2012
13 December 2012
04 September 2012
01 August 2012
25 May 2012
10 August 2013
28 February 2012
26 July 2012
04 June 2015
06 January 2011
WO 2012129258 A1
27 September 2012
EP 2688872 A1
US 2014194404 A1
WO 2012129258 A1
29 January 2014
10 July 2014
27 September 2012
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
24 June 2015
Date of mailing of the international search report:
07 July 2015
Authorized officer:
Gettins, Marc
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