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1. (WO2015002996) PRECISE DELIVERY OF THERAPEUTIC AGENTS TO CELL MITOCHONDRIA FOR ANTI-CANCER THERAPY

Pub. No.:    WO/2015/002996    International Application No.:    PCT/US2014/045131
Publication Date: 08.01.2015 International Filing Date: 01.07.2014
IPC: A61P 35/00
A61K 31/352
Applicants: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Inventors: SHANTA, Dhar
RAKESH, Pathak
Title: PRECISE DELIVERY OF THERAPEUTIC AGENTS TO CELL MITOCHONDRIA FOR ANTI-CANCER THERAPY
Abstract:
Described is a targeted molecular scaffold for construction of a metabolic inhibitor loaded with cancer-cell specific activity and anti-tumor immunity. Incorporation of a mitochondria targeting moiety such as triphenylphosphonium cation through a biodegradable linker in allowed for mitochondria targeting of certain metabolic inhibitors like dichloroacetic acid (DCA).