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1. (WO2012032035) SALTS OF 7-AMINO-3,5-DIHYDROXYHEPTANOIC ACID ESTERS
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CLAIMS

1. Salt of an organic acid with a compound of general formula (2)


wherein R1 and R2 are independently chosen from the list consisting of ethyl, hydrogen, methyl and propyl or combined into a diol protecting group such that the compound of general formula (2) is represented as a compound of formula (2a), (2b) or (2c)




2. Salt accord i ng to cl ai m 1 wherein said organic acid is an aliphatic monocarboxylic acid, dicarboxylic acid or polycarboxylic acid, cycloalkene carboxylic acid, aliphatic unsaturated carboxylic acid, aromatic carboxylic acid, heterocyclic carboxylic acid or sulfonic acid.

3. Salt according to claim 1 wherein said organic acid is chosen from the list consisting of acetic acid, benzenesulfonic acid, benzoic acid, 4-bromo-benzenesulfonic acid, 4-bromo-benzoic acid, 4-tert-butyl-benzoic acid, butyric acid, citric acid, cyclobutane carboxylic acid, cyclohexane carboxylic acid, cyclopentane carboxylic acid, cyclopropane carboxylic acid, fumaric acid, isovaleric acid, maleic acid, malic acid, malonic acid, methanesulfonic acid, 4-methoxy-benzoic acid, 4-methyl-benzenesulfonic acid, 3-methyl-benzoic acid, nicotinic acid, oxalic acid, pivalic acid, succinic acid, tetrahydrofurane-2-carboxylic acid, 2-thiophenecarboxylic acid, 3-thiophenecarboxylic acid and valeric acid.

4. Salt according to claim 1 wherein said organic acid is oxalic acid or pivalic acid and said compound of general formula (2) is the compound of formula (2a).


5. Method for the preparation of a salt of an organic acid with a compound of general formula (2)


wherein R2 and R2 are independently chosen from the list consisting of ethyl, hydrogen, methyl and propyl or combined into a diol protecting group such that the compound of general formula (2) is represented as a compound of formula (2a), (2b) or (2c)




comprising reacting said compound of general formula (2) with an organic acid in an organic solvent.

6. Method according to claim 5 wherein said organic acid is an aliphatic monocarboxylic acid, dicarboxylic acid or polycarboxylic acid, cycloalkene carboxylic acid, aliphatic unsaturated carboxylic acid, aromatic carboxylic acid, heterocyclic carboxylic acid or sulfonic acid.

7. Method according to claim 5 wherein said organic acid is acetic acid, benzenesulfonic acid, benzoic acid, 4-bromo-benzenesulfonic acid, 4-bromo-benzoic acid, 4-tert-butyl-benzoic acid, butyric acid, citric acid, cyclobutane carboxylic acid, cyclohexane carboxylic acid, cyclopentane carboxylic acid, cyclopropane carboxylic acid, fumaric acid, isovaleric acid, maleic acid, malic acid, malonic acid, methanesulfonic acid, 4-methoxy-benzoic acid, 4-methyl-benzenesulfonic acid, 3-methyl-benzoic acid, nicotinic acid, oxalic acid, pivalic acid, succinic acid, tetrahydrofurane-2-carboxylic acid, 2-thiophenecarboxylic acid, 3-thiophenecarboxylic acid or valeric acid.

8. Use of a salt of an organic acid with a compound of general formula (2)


wherein R1 and R2 are independently chosen from the list consisting of ethyl, hydrogen, methyl and propyl or combined into a diol protecting group such that the compound of general formula (2) is represented as a compound of formula (2a), (2b) or (2c)




in the preparation of a compound of formula (3)


or a pharmaceutically acceptable salt or ester thereof.

9. Use according to claim 8 wherein said salt of an organic acid with a compound of general formula (2) is converted to the amine of general formula (2) prior to conversion into said compound of formula (3).