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1. (WO2010027428) PLATINUM ( IV) COMPLEXES FOR USE IN DUAL MODE PHARMACEUTICAL THERAPY

Pub. No.:    WO/2010/027428    International Application No.:    PCT/US2009/004846
Publication Date: Fri Mar 12 00:59:59 CET 2010 International Filing Date: Thu Aug 27 01:59:59 CEST 2009
IPC: A61K 31/19
A61K 33/24
A61K 45/06
A61P 35/00
Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
LIPPARD, Stephen, J.
DHAR, Shanta
Inventors: LIPPARD, Stephen, J.
DHAR, Shanta
Title: PLATINUM ( IV) COMPLEXES FOR USE IN DUAL MODE PHARMACEUTICAL THERAPY
Abstract:
The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects in need of therapeutic protocol, including subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a first component comprising a precursor to a therapeutically active platinum agent and a precursor to a second therapeutically active agent. The therapeutically active platinum agent and the second therapeutically active agent may dissociate from each other, thereby forming a first therapeutically active platinum agent and a second therapeutically active agent. The second therapeutically active gent may affect a cellular pathway of a cancer cell and may be substantially inactive towards non-cancerous cells.