Suche in nationalen und internationalen Patentsammlungen

1. (WO2003018015) PHARMACEUTICAL COMPOSITION FOR PREVENTING DRUG ABUSE BY PPRODUCING MUSOUS MEMBRANE IRRITATION

Pub. No.:    WO/2003/018015    International Application No.:    PCT/EP2002/009660
Publication Date: 06.03.2003 International Filing Date: 29.08.2002
IPC: A61K 9/00
A61K 9/20
A61K 9/48
A61K 31/137
A61K 31/4458
Applicants: NOVARTIS AG
NOVARTIS PHARMA GMBH
JOSHI, Yatindra
SOMMA, Russell
Inventors: JOSHI, Yatindra
SOMMA, Russell
Title: PHARMACEUTICAL COMPOSITION FOR PREVENTING DRUG ABUSE BY PPRODUCING MUSOUS MEMBRANE IRRITATION
Abstract:
A pharmaceutical composition which reduces or eliminates the drug abuse potential of central nervous system stimulant comprising: (a) a central nervous system stimulant selected from the group consisting of methylphenidate, amphetamine, methamphetamine, and combinations thereof; and (b) a mucous membrane irritant selected from the group consisting of organic and inorganic acid, salt, ketone, nitrite, sulfide, bisulfate, persulfate, glycerophosphate, hypophosphate, borate, titanate, amino acid, peptide, and combinations thereof, wherein the mucous membrane irritant produces, irritation when contacted with the skin or mucous membrane. The present invention is based on the discovery that a central nervous system stimulant, such as methylphenidate, in combination with a mucous membrane irritant, such as citric acid, reduces or eliminates potential drug abuse by producing 'irritation' when contacted with the dermis layer of skin or mucous membrane, and thus, prevents nasal absorption and/or injectability of the drug.