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1. (WO2003004470) CRYSTALLINE FORMS OF 'R-(R*,R*)!-2-(4-FLUOROPHENYL)-BETA, DELTA-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-'PHENYLAMINO)CARBONYL!-1H-PYRROLE-1-HEPTANOIC ACID CALCIUM SALT (2:1) (ATORVASTATIN)
Anmerkung: Text basiert auf automatischer optischer Zeichenerkennung (OCR). Verwenden Sie bitte aus rechtlichen Gründen die PDF-Version.

CLAIMS

What is claimed is:

1. A crystalline Form V atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 29 values measured using
CuKα radiation: 4.9 (broad), 6.0, 7.0, 8.0 (broad), 8.6, 9.9, 16.6, 19.0, and

21.1.

2. A crystalline Form VI atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 2Θ values measured using
CuKα radiation: 7.2, 8.3, 11.0, 12.4, 13.8, 16.8, 18.5, 19.7 (broad), 20.9, and 25.0.

3. A crystalline Form VII atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 29 values measured using
CuKα radiation: 8.6, 10.2, 12.4 (broad), 12.8 (broad), 17.6, 18.3 (broad), 19.3, 22.2 (broad), 23.4 (broad), 23.8 (broad), and 25.5 (broad).

4. A crystalline Form VIII atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 2Θ values measured using
CuKα radiation: 7.5, 9.2, 10.0, 12.1, 12.8, 13.8, 15.1, 16.7 (broad), 18.6
(broad), 20.3 (broad), 21.2, 21.9, 22.4, 25.8, 26.5, 27.4 (broad), and 30.5.

5. A crystalline Form IX atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 2Θ values measured using
CuKα radiation: 8.8, 9.4 (broad), 11.2-11.7 (broad), 16.7, 17.5 (broad),
19.3 (broad), 21.4 (broad), 22.4 (broad), 23.2 (broad), and 29.0 (broad).

6. A crystalline Form X atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 29 values measured using CuKo- radiation: 4.7, 5.2, 5.8, 6.9, 7.9, 9.2, 9.5, 10.3 (broad), 11.8, 16.1, 16.9, 19.1, 19.8, 21.4, 22.3 (broad), 23.7 (broad), 24.4, and 28.7.

7. A crystalline Form XI atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 29 values measured using
CuKα radiation: 10.8 (broad), 12.0, 13.5, 16.5, 17.6-18.0 (broad), 19.7,
22.3, 23.2, 24.4, 25.8, 26.5, 27.3, 28.7, 29.5, 30.9 (broad), 32.8 (broad),
33.6 (broad), 36.0 (broad), and 38.5 (broad).

8. A crystalline Form XII atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 29 values measured using
CuKα radiation: 5.4, 7.7, 8.0, 8.6, 8.9, 9.9, 10.4 (broad), 12.5, 13.9
(broad), 16.2, 17.8, 19.4, 20.8, 21.7, 22.4-22.6 (broad), 24.3, 25.5, 26.2, and 27.1.

9. A crystalline Form XIII atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 29 values measured using
CuKα radiation: 8.4, 8.9, 15.7 (broad), 16.4 (broad), 17.6 (broad), 18.1
(broad), 19.7 (broad), 20.8 (broad), and 23.8 (broad).

10. A crystalline Form XIV atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 29 values measured using
CUKQ. radiation: 5.4, 6.7, 7.7, 8.1, 9.0, 16.5 (broad), 17.6 (broad),
18.0-18.7 (broad), and 19.5 (broad).

11. A crystalline Form XV atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 29 values measured using
CuKα radiation: 5.7, 6.1, 6.8, 7.5, 8.1, 8.5, 9.5, 10.5 (broad), and 19.1-19.6 (broad).

12. A crystalline Form XVI atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 29 values measured using
CuKα radiation: 5.2, 6.4, 7.5, 8.7, 10.5 (broad), 12.0 (broad), 12.7 (broad), 16.7, 18.3 (broad), 19.5, 20.1-20.4 (broad), 21.2-21.9 (broad), 22.9-23.3
(broad), and 24.4-25.0 (broad).

13. A crystalline Form XVII atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 29 values measured using
CuKα radiation: 5.0, 6.1, 7.3, 7.9, 8.5, 9.1, 10.0, 12.1 (broad), 14.8,
16.0-16.5 (broad), 17.5 (broad), 19.0 (broad), 19.5, 20.2 (broad), 21.3,
21.6, and 22.0.

14. A crystalline Form XVIII atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 29 values measured using
CuKα radiation: 8.0, 9.2 (broad), 9.7 (broad), 12.1, 16.6 (broad), and 18.5.

15. A crystalline Form XIX atorvastatin or a hydrate thereof having an X-ray powder diffraction containing the following 29 values measured using
CuKα radiation: 5.2, 6.3, 7.0, 8.6, 10.5, 11.6 (broad), 12.7 (broad), 14.0,
16.7 (broad), 18.9, 20.8, 23.6 (broad), and 25.5 (broad).