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1. (WO2002088736) PRENATAL DIAGNOSIS METHOD ON ISOLATED FOETAL CELL OF MATERNAL BLOOD

Pub. No.:    WO/2002/088736    International Application No.:    PCT/FR2002/001505
Publication Date: Fri Nov 08 00:59:59 CET 2002 International Filing Date: Wed May 01 01:59:59 CEST 2002
IPC: C12Q 1/68
G01N 33/68
Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
UNIVERSITE RENE DESCARTES PARIS 5
PATERLINI-BRECHOT, Patrizia
Inventors: PATERLINI-BRECHOT, Patrizia
Title: PRENATAL DIAGNOSIS METHOD ON ISOLATED FOETAL CELL OF MATERNAL BLOOD
Abstract:
The invention concerns a novel non-invasive prenatal diagnostic method implemented with a sample of maternal blood. Said method enables prenatal diagnosis on isolated non-apoptotic epithelial foetal cells of maternal blood after they have been enriched by filtration, morphologically or immunologically and genetically analysed. Said method is advantageous in that it is perfectly harmless for the mother and the foetus and provides a highly sensitive and specific diagnosis. It enables early detection of a genetic or chromosomal abnormality of the foetus, of a genetic or infectious (viral, bacterial or parasitic) pathology of the foetus, of accurate genotype, and in particular of the genetic sex of the foetus.