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1. (WO1998003653) METHOD FOR PREPARING TRANSGENIC NON-HUMAN MAMMALIAN ORGANS FOR TRANSPLANTATION TO HUMANS, AND NUCLEOTIDE SEQUENCES THEREFOR

Pub. No.:    WO/1998/003653    International Application No.:    PCT/FR1997/001340
Publication Date: Fri Jan 30 00:59:59 CET 1998 International Filing Date: Sat Jul 19 01:59:59 CEST 1997
IPC: A01K 67/027
C07K 16/28
C12N 15/85
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
VANHOVE, Bernard
POURCEL, Christine
SOULILLOU, Jean-Paul
Inventors: VANHOVE, Bernard
POURCEL, Christine
SOULILLOU, Jean-Paul
Title: METHOD FOR PREPARING TRANSGENIC NON-HUMAN MAMMALIAN ORGANS FOR TRANSPLANTATION TO HUMANS, AND NUCLEOTIDE SEQUENCES THEREFOR
Abstract:
The use of nucleotide sequences coding for antibodies to any molecule involved in a graft versus host reaction (hereinafter anti-molecule antibodies), for preparing transgenic cells or organs of non-human mammals, wherein said molecules at least partially form immune complexes with said anti-molecule antibodies, such that the activity of said molecules in graft versus host reactions is at least partially inhibited, said transgenic cells or organs of non-human mammals being intended for transplantation into a patient, is disclosed.