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1. EP2077119 - Behandlung von Fibrosen und Lebererkrankungen

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Amt
Europäisches Patentamt (EPA)
Aktenzeichen/Anmeldenummer 07450239
Anmeldedatum 21.12.2007
Veröffentlichungsnummer 2077119
Veröffentlichungsdatum 08.07.2009
Veröffentlichungsart A1
IPC
A61K 38/55
ASektion A Täglicher Lebensbedarf
61Medizin oder Tiermedizin; Hygiene
KZubereitungen für medizinische, zahnärztliche oder kosmetische Zwecke
38Medizinische Zubereitungen, die Peptide enthalten
16Peptide mit mehr als 20 Aminosäuren; Gastrine; Somatostatine; Melanotropine; Derivate davon
55Proteaseinhibitoren
A61K 38/48
ASektion A Täglicher Lebensbedarf
61Medizin oder Tiermedizin; Hygiene
KZubereitungen für medizinische, zahnärztliche oder kosmetische Zwecke
38Medizinische Zubereitungen, die Peptide enthalten
16Peptide mit mehr als 20 Aminosäuren; Gastrine; Somatostatine; Melanotropine; Derivate davon
43Enzyme; Proenzyme; Derivate davon
46Hydrolasen (3)
48einwirkend auf Peptidverbindungen (3.4)
CPC
A01K 67/0276
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
0275Genetically modified vertebrates, e.g. transgenic
0276Knockout animals
A01K 2207/30
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2207Modified animals
30Animals modified by surgical methods
A01K 2217/075
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
07Animals genetically altered by homologous recombination
075inducing loss of function, i.e. knock out
A01K 2227/105
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
105Murine
A01K 2227/108
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
108Swine
A01K 2267/03
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
Anmelder APEIRON BIOLOG FORSCHUNGS UND
Erfinder LOIBNER HANS
SCHUSTER MANFRED
OESTERREICHER CHRISTOPH
Designierte Staaten
Prioritätsdaten 07450239 21.12.2007 EP
Titel
(DE) Behandlung von Fibrosen und Lebererkrankungen
(EN) Treatment of fibrosis and liver diseases
(FR) Traitement de fibroses et de maladies du foie
front page image
Zusammenfassung
(DE) Die vorliegende Erfindung betrifft ACE2 zur therapeutischen Behandlung oder Vorbeugung einer Fibrose oder Lebererkrankung.
(EN) Angiotensin converting enzyme 2 protein or nucleic acid is used to treat or prevent fibrosis or liver disease. ACTIVITY : Cytostatic; Hepatotropic. MECHANISM OF ACTION : Collagen production inhibitor. After bile duct ligation, mice were treated with recombinant angiotensin converting enzyme 2 protein by intravenous injection at a dose of 2 mg/kg once a day for 14 days. Collagen-producing cells were monitored by smooth muscle actin (SMA) assay. The numbers of such cells increased greatly in the damaged livers of untreated mice, whereas SMA was not detectable in the livers of the treated mice.
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