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1. (WO2005121109) NOVEL ANTIVIRAL MACROCYCLE DERIVATIVES AND METAL COMPLEXES, INCORPORATING BRIDGED MACROCYCLES

Pub. No.:    WO/2005/121109    International Application No.:    PCT/GB2005/002297
Publication Date: Fri Dec 23 00:59:59 CET 2005 International Filing Date: Sat Jun 11 01:59:59 CEST 2005
IPC: C07D 487/08
A61K 31/395
Applicants: UNIVERSITY OF HULL
ARCHIBALD, Stephen, James
LEWIS, Elizabeth, Amie
HUBIN, Timothy, J.
Inventors: ARCHIBALD, Stephen, James
LEWIS, Elizabeth, Amie
HUBIN, Timothy, J.
Title: NOVEL ANTIVIRAL MACROCYCLE DERIVATIVES AND METAL COMPLEXES, INCORPORATING BRIDGED MACROCYCLES
Abstract:
A compound of Formulae (1), (2) or (3), A1-Ph (1) or A1-Ar-A2 (2) or A1-(A2)A’-A3 (3) wherein A1, A2 and A3 are selected from Formulae (4), (5) and (6), or a salt whereof; wherein Ar is selected from the group consisting of 1,2-phenyl, 1,3-phenyl and 1,4-phenyl optionally substituted with one or more methyl groups; m and n are independently integers from 0 to l; Ph is phenyl, optionally substituted with one or more methyl groups; Arl is trisubstituted phenyl optionally substituted with one or more phenyl groups; and R1, R2 and R3 are independently selected from the group consisting of H, Me and linear chain C2- C4 alkyl.