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1. (WO2007029689) METHOD FOR ACTIVATION TREATMENT OF ANTIGEN-PRESENTING CELL

Pub. No.:    WO/2007/029689    International Application No.:    PCT/JP2006/317535
Publication Date: Fri Mar 16 00:59:59 CET 2007 International Filing Date: Wed Sep 06 01:59:59 CEST 2006
IPC: A61K 35/12
A61P 31/00
A61P 35/00
C12N 5/0783
Applicants: MEDINET CO., LTD.
株式会社メディネット
NIEDA, Mie
贄田美江
ISOGAI, Manami
磯貝まなみ
TAKAHARA, Masashi
高原将司
NICOL, Andrew
ニコル アンドリュー
Inventors: NIEDA, Mie
贄田美江
ISOGAI, Manami
磯貝まなみ
TAKAHARA, Masashi
高原将司
NICOL, Andrew
ニコル アンドリュー
Title: METHOD FOR ACTIVATION TREATMENT OF ANTIGEN-PRESENTING CELL
Abstract:
An activated antigen-presenting cell capable of inducing an immunocompetent cell including a disease antigen-specific CD8+CTL and/or a ϜδT cell in vivo and/or in vitro with good efficiency; a pharmaceutical comprising the activated antigen-presenting cell; a therapeutic/prophylactic method using the activated antigen-presenting cell; a method for induction of an immunocompetent cell including a disease antigen-specific CD8+CTL and/or a ϜδT cell which is induced by using the activated antigen-presenting cell; an immunocompetent cell induced by the method; a pharmaceutical comprising the immunocompetent cell; and a therapeutic/prophylactic method using the immunocompetent cell. An antigen-presenting cell is sensitized with a disease antigen and also co-sensitized with bisphosphonate, thereby producing an increased number of a disease antigen-specific CD8+CTL and/or a ϜδT cell at a higher ratio compared to a method without co-sensitization with bisphosphonate.