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1. (WO2014204429) METHODS AND APPARATUS FOR STIMULATING AND RECORDING NEURAL ACTIVITY

Pub. No.:    WO/2014/204429    International Application No.:    PCT/US2013/046103
Publication Date: Thu Dec 25 00:59:59 CET 2014 International Filing Date: Tue Jun 18 01:59:59 CEST 2013
IPC: A61B 5/04
A61B 5/0478
Applicants: THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventors: ANIKEEVA, Polina Olegovna
JIA, Xiaoting
LU, Chi
CANALES, Andres
FROFIEP, Ulrich Paul
TRINGIDES, Christina Myra
FINK, Yoel
Title: METHODS AND APPARATUS FOR STIMULATING AND RECORDING NEURAL ACTIVITY
Abstract:
Thermal drawing processes can be used to make multifunctional, high-resolution neural probes for neural recording and stimulation. An exemplary neural probe may include one or more conductive fibers or microelectrodes coated with two or more layers of insulating material, at least one of which is partially etched to expose a tip at the neural probe's distal end. The conductive fibers conduct electrical signals (e.g., neural spikes or electrical stimulation) between the tip and the neural probe's proximal end. Optional optical and fluidic waveguides may guide light and fluid, respectively, between the tip and the proximal end. A neural probe may be flexible enough for long-term (chronic) implantation in neural tissue (e.g., the brain) without excessive tissue damage, even during movement of the brain in the skull. The probe may be made from biocompatible materials, such as insulating and conductive polymers, that have negligible (insignificant) interaction with the surrounding tissue.