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1. (CN104922131) Micro-pill containing tegafur, gimeracil and potassium oxonate, capsule preparation and preparation method for micro-pill

المكتب : الصين
رقم الطلب: 201510262917.3 تاريخ الطلب: 19.05.2015
رقم النشر: 104922131 تاريخ النشر: 23.09.2015
نوع النشر: A
التصنيف الدولي للبراءات:
A61K 31/53
A61K 9/16
A61K 9/48
A61K 47/02
A61K 47/04
A61P 35/00
A61K 31/4412
A61K 31/513
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المتقدمون: JIANGSU YUNYANG PHARMACEUTICAL GROUP CO., LTD.
المخترعون: BAO XIAOFANG
JIANG FEI
LI YAN
بيانات الأولوية:
العنوان: (EN) Micro-pill containing tegafur, gimeracil and potassium oxonate, capsule preparation and preparation method for micro-pill
(ZH) 一种含替加氟、吉美拉西和奥体拉西钾的微丸和胶囊制剂及其制备方法
الملخص:
(EN) The invention discloses a micro-pill containing tegafur, gimeracil and potassium oxonate, a capsule preparation and a preparation method for the micro-pill. The micro-pill comprises a tegafur drug layer-coated pill core, an isolation layer and a coating layer containing gimeracil and potassium oxonate. Tegafur, gimeracil and potassium oxonate are ground by airflow, the micro-pill is directly coated with a drug through an empty pill core, additional auxiliary materials are prepared into granules by a fluidized bed, the micro-pill is uniformly mixed with the additional auxiliary material granules, and a capsule is directly filled with a mixture. The prepared capsule is capable of enabling the drug to be stably and quickly released in bodies, remarkably improves the content uniformity and stability of the drug, has relatively high dissolution rate and bioavailability, reduces adverse drug reactions and can be commercially produced.
(ZH)

本发明公开了一种含有替加氟、吉美拉西和奥替拉西钾的微丸及胶囊制剂及其制备方法,所述微丸包括表面包覆有替加氟药物层的丸芯、隔离层和含有吉美拉西和奥替拉西钾的包衣层。经过将替加氟、吉美拉西和奥替拉西钾气流粉碎后,通过空白丸芯直接微丸上药包衣,外加辅料流化床制备颗粒,再将微丸和外加辅料颗粒混合均匀后,直接填充胶囊。本发明制备的胶囊能够使药物在体内平稳快速释放,显著提高了药物的含量均匀度和稳定性,有较好的溶出度和生物利用度,降低了药物的不良反应,并能商业化生产。