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1. (WO2019043723) EMULSIONS FOR OPHTHALMIC DELIVERY OF ANTIOXIDANTS
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CLAIMS

We claim

1. A stable oil-in-water ophthalmic emulsion for ocular delivery of antioxidants comprising one or more antioxidants as an active pharmaceutical ingredient, at least one oil of vegetable, mineral or animal origin or a combination thereof, at least one surfactant and at least one pharmaceutically acceptable excipient, wherein the pFI is in the range of about 4 to 8.

2. The stable oil-in-water ophthalmic emulsion of claim 1, wherein the antioxidant is selected from the group comprising of lutein, zeaxanthin, tocopherol, beta carotene, selenium or a combination thereof.

3. The stable oil-in-water ophthalmic emulsion of claim 1 , wherein theconcentration of antioxidant is in the range of about 0.0003%-0.3% w/v.

4. The stable oil-in-water ophthalmic emulsion of claim 1, wherein the oil is a vegetable oil or mineral oil or animal oil or a combination thereof,

5. The stable oil-in-water ophthalmic emulsion of claim 1, wherein the vegetable oil is selected from the group comprising of Castor Oil, Cotton seed Oil, Peanut Oil, Coconut oil, Rice bran oil, Sunflower oil, Sesame oil, Soyabeen oil, Flax oil, Canoia oil, Olive oil, Mustard Oil, Jojoba oil or a combination thereof.

6. The stable oil-in-water ophthalmic emulsion of claim 1 , wherein the animal oil is selected from the group comprising of fish oil, shark liver oil, cod liver oil or a combination thereof.

7. The stable oil-in-water ophthalmic emulsion of claim 1, wherein the mineral oil is Liquid Paraffin and White Mineral Oil or a combination thereof.

8. The stable oil-in-water ophthalmic emulsion of claim 1 , wherein the surfactant is selected from the group comprising of Polyoxyethylated nonionic surfactants like PolysorbateSO, Polysorbate 60, Polysorbate, 40, Polysorbate 20, Cremophors, Tyloxapols, Poloxamers, Benzalkonium chloride, Benzethonium chloride, Cetyl alcohol, Carbomer, Cholesterol, Cocamidopropyl betaine, glyceryl monostearate, lanolin alcohols, lauralkonium chlorides, N lauroylsarcosine, Nonoxynol 9, Octoxynol 40, Polyoxyl 35 castor oil, Polyoxyl 40 hydrgenated castor oil. Polyoxyl 40 stearate, Sorbitanmonolaureate, Sorbitan monooleate, Sorbitanmonopalmitate, Polyoxyethylene (2) Steryl Ether, Polyoxyethylene (2) Cetyl Ether, Polyoxyethylene (2) Qleyl Ether, Polyeoxyethyllene (2) Nonylphenylether, Polyoxyethylene (2) isooctylphenyl ether, Polyoxyletheylene (4) lauryl ether, Polyoxylethylene (5) isooctylphenylether or a combination thereof.

9. The stable oil-in-water ophthalmic emulsion of claim 1, further comprises at least one pH adjusting agent selected from the group comprising of Hydrochloric Acid, Sodium Hydroxide, Sulphuric Acid, Sodium Sulphate, Acetic Acid, Sodium Citrate, Ammonium Hydroxide, Citric Acid, Diethanoiamine, Nitric Acid, Phosphoric Acid or a combination thereof.

10. The stable oil-in-water ophthalmic emulsion of claim 1, further comprises at least one buffering agent selected from the group comprising of Acetic Acid, Boric Acid, Citric Acid, Phosphoric Acid, Potassium Acetate, Potassium Phosphate, Potassium Sulphate, Potassium Sorbate, Sodium Acetate, Sodium borate, Sodium Carbonate, Sodium Citrate, Sodium Phosphate, Sorbic Acid, Tromethamine or a combination thereof.

11. The stable oil-in-water ophthalmic emulsion of claim ] , further comprises at least one osmolarity control agent selected from the group comprising of Sodium Chloride, Sodium Sulphate, Sodium Nitrate, Sorbitol, Mannitol, Calcium Chloride, Glycerine, Magnesium Chloride, PEC} 300, PEG 400, Potassium Chloride, Propylene Glycol or a combination thereof.

12. The stable oil-in-water ophthalmic emulsion of claim 1 , further comprises at least one antimicrobial preservative selected from the group comprising of Quaternary ammonium compounds selected from Benzalkonium Chloride, Benzethonium chloride, Benzododecinium bromide or Polyquatermium- 1 ;or Acid/Base compounds selected from Boric acid, sodium acetate or sodium borate ;or Alcohols selected fromchlorobutanol or Phenylethyl alcohol;or Organic Mercuric compounds selected from Phenyl mercuric acetate, Phenyl mercuric nitrate or Thimerosal; or Parabens selected from methyl paraben or Propyl Paraben;or Oxidizing agent sodium chlorite; or Metal salt Zinc Chloride or a combination thereof.