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1. (WO2019043234) RETINAL PROMOTER AND USES THEREOF



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2018/073643 P185941.WO.01
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
03 September 2018 01 September 2017
Applicant
THE PROVOST, FELLOWS AND SCHOLARS OF THE...
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C12N 15/85 (2006.01)i; A61K 48/00 (2006.01)i; C12N 5/079 (2010.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C12N; A61K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, EMBL, BIOSIS

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
ELDER G A ET AL, "Novel DNA binding proteins participate in the regulation of human neurofilament H gene expression", 01 September 1992 (1992-09-01), Vol. 15, No. 1-2, page 85-98,
XP024331773
[retrieved on  1992-09-01]
23,48,50-52,54
Whole document especially figure 1
(2)
Y
WO 2017093566 A1 (UNIV PIERRE ET MARIE CURIE [FR]; INSERM (INSTITUT NAT DE LA SANTÉ ET) 08 June 2017 (2017-06-08)
1-22,38-57
Whole document, especially the claims.
(3)
Y
Chan Y Kim ET AL, "Gene expression profile of the adult human retinal ganglion cell layer", United States 22 December 2006 (2006-12-22), page 1640-8,
Retrieved from the Internet:
URL:http://www.molvis.org/molvis/v12/a188/v12a188-kim.pdf
XP055520855
[retrieved on  2018-11-02]
1-22,38-57
cited in the application
Whole document, especially table 2
(4)
A
MICHAEL L SCHWARTZ ET AL, "Brain-specific Enhancement of the Mouse Neurofilament Heavy Gene Promoter in vitro", J BIOL CHEM.,Vol. 269, No. 18, 01 January 1994 (1994-01-01), page 13444-13450,
XP055520822
1-57
the whole document
(5)
A
ZHANG G-R ET AL, "A tyrosine hydroxylase-neurofilament chimeric promoter enhances long-term expression in rat forebrain neurons from helper virus-free HSV-1 vectors", MOLECULAR BRAIN RESEARCH, ELSEVIER SCIENCE BV, AMSTERDAM, NL,Vol. 84, 01 January 2000 (2000-01-01), page 17-31,
XP002904376
1-57
Whole document, especially figure 1B.
(6)
A
GAO ET AL, "Isolation of an enhancer from the rat tyrosine hydroxylase promoter that supports long-term, neuronal-specific expression from a neurofilament promoter, in a helper virus-free HSV-1 vector system", BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL,Vol. 1130, 26 January 2007 (2007-01-26), page 1-16,
XP022030849
1-57
the whole document
(7)
X,P
KILLIAN S. HANLON ET AL, "A Novel Retinal Ganglion Cell Promoter for Utility in AAV Vectors", FRONTIERS IN NEUROSCIENCE,Vol. 11, 21 September 2017 (2017-09-21),
XP055520701
1-57
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2017093566 A1
08 June 2017
AU 2016363830 A1
CA 3004807 A1
EP 3384036 A1
WO 2017093566 A1
17 May 2018
08 June 2017
10 October 2018
08 June 2017
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
05 November 2018
Date of mailing of the international search report:
16 November 2018
Authorized officer:
Kools, Patrick
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