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1. (WO2019008029) SULFONYLUREAS AND SULFONYLTHIOUREAS AS NLRP3 INHIBITORS
أحدث البيانات الببلوغرافية المتوفرة لدى المكتب الدولي    تقديم ملاحظات

رقم النشر: WO/2019/008029 رقم الطلب الدولي: PCT/EP2018/068081
تاريخ النشر: 10.01.2019 تاريخ الإيداع الدولي: 04.07.2018
التصنيف الدولي للبراءات:
C07D 239/56 (2006.01) ,C07D 213/71 (2006.01) ,C07D 401/12 (2006.01) ,C07D 237/18 (2006.01) ,C07D 237/20 (2006.01) ,C07D 237/24 (2006.01) ,C07D 239/40 (2006.01) ,C07D 239/47 (2006.01) ,C07D 241/18 (2006.01) ,C07D 241/20 (2006.01) ,C07D 241/24 (2006.01) ,C07D 241/44 (2006.01) ,C07D 471/04 (2006.01) ,A61P 31/00 (2006.01) ,A61P 25/28 (2006.01) ,A61P 29/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 3/10 (2006.01) ,A61K 31/4965 (2006.01) ,A61K 31/50 (2006.01) ,A61K 31/505 (2006.01) ,A61K 31/44 (2006.01) ,A61K 31/4412 (2006.01) ,A61K 31/437 (2006.01) ,A61K 31/444 (2006.01) ,A61K 31/497 (2006.01) ,A61K 31/506 (2006.01) ,A61K 31/501 (2006.01)
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المودعون:
INFLAZOME LIMITED [IE/IE]; 88 Harcourt Street Dublin 2, IE
المخترعون:
COOPER, Matthew; GB
MILLER, David; GB
MACLEOD, Angus; GB
VAN WILTENBURG, Jimmy; NL
THOM, Stephen; GB
ST-GALLAY, Stephen; GB
SHANNON, Jonathan; GB
الوكيل:
JOHNSON, Stephen; GB
ANDERSON, Oliver; GB
BROWN, Alexander; GB
CHETTLE, John; GB
CLARK, Jonathan; GB
COLONNA, Matthew; GB
CORK, Robert; GB
DAINTY, Katherine; GB
DERRY, Paul; GB
FLETCHER, Scott; GB
GILL, Siân; GB
GREY, Ian; GB
HANDLEY, Matthew; GB
HARRISON, Philip; GB
HEWETT, Jonathan; GB
HUDSON, George; GB
HUTTER, Anton; GB
JUMP, Timothy; GB
KENNEDY, Richard; GB
LEANSE, Thomas; GB
MAYS, Julie; GB
MCDOUGALL, James; GB
NEWCOMBE, Christopher; GB
PETTY, Catrin; GB
ROGAN, Jack; GB
RUSSELL, Tim; GB
SAYER, Robert; GB
TAOR, Simon; GB
WALASKI, Jan; GB
WHITING, Gary; GB
DUNLEAVY, Christopher; GB
ELEND, Almut; GB
GILANI, Anwar; GB
MCNAMARA, Kathryn; GB
PIOTROWICZ, Pawel; GB
SHELTON, Ruth; GB
بيانات الأولوية:
1710942.207.07.2017GB
1713076.615.08.2017GB
1713082.415.08.2017GB
1718563.809.11.2017GB
1721726.622.12.2017GB
العنوان (EN) SULFONYLUREAS AND SULFONYLTHIOUREAS AS NLRP3 INHIBITORS
(FR) SULFONYLURÉES ET SULFONYLTHIOURÉES EN TANT QU'INHIBITEURS DE NLRP3
الملخص:
(EN) The present invention relates to compounds of formula (I): wherein Q is O or S, R1 is a 6-membered heteroaryl group containing at least one nitrogen atom in the 6-membered ring structure, wherein R1 may optionally be substituted, and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.
(FR) La présente invention concerne des composés de formule (I) : dans laquelle Q représente O ou S ; R1 représente un groupe hétéroaryle à 6 chaînons contenant au moins un atome d’azote dans la structure cyclique à 6 chaînons, R1 pouvant être éventuellement substitué, et R2 est un groupe cyclique substitué en position α, R2 pouvant être éventuellement substitué. La présente invention concerne en outre des sels, des solvates et des promédicaments de tels composés, des compositions pharmaceutiques comprenant lesdits composés, et l'utilisation de tels composés dans le traitement et la prévention de troubles médicaux et de maladies, plus particulièrement par inhibition de NLRP3.
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الدول المعيّنة: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
المنظمة الإقليمية الأفريقية للملكية الفكرية (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
مكتب البراءات الأوروبي الآسيوي (AM, AZ, BY, KG, KZ, RU, TJ, TM)
المكتب الأوروبي للبراءات (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
المنظمة الأفريقية للملكية الفكرية (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
لغة النشر: الإنكليزية (EN)
لغة الإيداع: الإنكليزية (EN)