البحث في مجموعات البراءات الوطنية والدولية

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1. (WO2017141204) BIGUANIDE GRAFTED / MODIFIED BIOPOLYMERS AS DRUG DELIVERY VEHICLES

Pub. No.:    WO/2017/141204    International Application No.:    PCT/IB2017/050909
Publication Date: Fri Aug 25 01:59:59 CEST 2017 International Filing Date: Sat Feb 18 00:59:59 CET 2017
IPC: C08F 291/00
Applicants: CHINDERA, Kantaraja
Inventors: CHINDERA, Kantaraja
Title: BIGUANIDE GRAFTED / MODIFIED BIOPOLYMERS AS DRUG DELIVERY VEHICLES
Abstract:
The present invention is related to the compounds and methods having entry promoting (broadly referred as drug delivery) properties. It particularly relates to entry promoting agents for delivery of proteins, polypeptides and analogues; nucleic acids and analogues; small molecules (often referred to as drugs including antimicrobials) with applications in research or medicinal/therapeutic use. More specifically it relates to existing biodegradable natural polymers or proteins or polypeptides or peptides or synthetic biopolymers decorated with biguanidine. It also relates to the method of synthesis/modification of biomolecules with biguanidine. Further aspect of the invention relates to the composition and method for entry promoting (delivery) of therapeutics or prophylactics or imaging agents or agents used in research or therapy. The method for promoting entry of an agent (introduced agent) into a eukaryotic or prokaryotic cell, the method comprising the step of exposing the cell to the introduced agent in the presence of an entry-promoting agent, wherein the entry-promoting agent comprises a linear and/or branched or dendrimeric, natural (carbohydrates or protein, polypeptides or peptides or polyamines), synthetic or semisynthetic polymer (amine bearing polymers) having a substituted biguanidine moieties (0.01 - 100%).