البحث في مجموعات البراءات الوطنية والدولية

1. (WO2017138586) INFLAMMASOME ACTIVATION INHIBITOR

Pub. No.:    WO/2017/138586    International Application No.:    PCT/JP2017/004648
Publication Date: Fri Aug 18 01:59:59 CEST 2017 International Filing Date: Thu Feb 09 00:59:59 CET 2017
IPC: A61K 31/365
A23L 33/105
A61K 8/49
A61K 8/97
A61K 31/7048
A61K 36/28
A61K 36/634
A61P 1/16
A61P 3/04
A61P 3/10
A61P 9/00
A61P 9/10
A61P 13/12
A61P 17/00
A61P 17/06
A61P 25/16
A61P 25/28
A61P 27/02
A61P 27/14
A61P 29/00
A61P 31/00
A61P 37/08
A61Q 19/00
Applicants: KRACIE HOLDINGS, LTD
クラシエホールディングス株式会社
Inventors: WATANABE Shimpei
渡部 晋平
ARAI Ayako
荒居 彩子
TAKAJO Yuichi
高城 雄一
INAMASU Satoshi
稲益 悟志
YOMODA Satoshi
与茂田 敏
OHNO Akiko
大野 晶子
KITAHARA Yuko
北原 裕子
KANATANI Taisaku
金谷 太作
Title: INFLAMMASOME ACTIVATION INHIBITOR
Abstract:
To provide a novel inflammasome inhibitor capable of inhibiting the activation of inflammasome, the present inventors newly found that arctigenin reduces the release amount of 1L-1β and the amount of activated caspase-1 upon stimulation with ATP, palmitic acid, MSU and Poly(dA:dT) and thus has an effect of inhibiting inflammasome activation. The present invention provides an inflammasome activation inhibitor that comprises arctigenin as an active ingredient.