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1. (WO2017114851) METHODS FOR PREDICTING THE SURVIVAL TIME OF PATIENTS SUFFERING FROM A MICROSATELLITE UNSTABLE CANCER



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2016/082745 DUVAL15533MC
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
28 December 2016 29 December 2015
Applicant
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA...
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
This International Searching Authority found multiple inventions in this international application, as follows:
1. claims: 1-15(partially)
Method for predicting the survival time of a patient suffering from a microsatellite unstable colorectal cancer and a method for determining whether a patient suffering from a microsatellite unstable colorectal cancer will achieve a response with an immune checkpoint inhibitor comprising i) determining the expression level of the gene encoding for IDO-1 in a tumor tissue sample obtained from the patient, and ii) comparing the expression level determined at step i) with a predetermined reference value; and a method of treating the thus identified patients.
2-15. claims: 1-15(partially)
Method for predicting the survival time of a patient suffering from a microsatellite unstable colorectal cancer and a method for determining whether a patient suffering from a microsatellite unstable colorectal cancer will achieve a response with an immune checkpoint inhibitor comprising i) determining the expression level of at least one gene selected from the group consisting of CD40, CD274, ICOS, TNFRSF9, TNFRSF18, LAG3, IL2RB, HAVCR2, TNFRSF4, CD276, CTLA4, PDCD1LG2, VTCN 1 and PDCD 1 in a tumor tissue sample obtained from the patient, and ii) comparing the expression level determined at step i) with a predetermined reference value; and a method of treating the thus identified patients.
1.
As all required additional search fees were timely paid by the applicant, this international search report covers all searchable claims.
2.
As all searchable claims could be searched without effort justifying additional fees, this Authority did not invite payment of additional fees.
3.
As only some of the required additional search fees were timely paid by the applicant, this international search report covers only those claims for which fees were paid, specifically claims Nos.:
4.
No required additional search fees were timely paid by the applicant. Consequently, this international search report is restricted to the invention first mentioned in the claims; it is covered by claims Nos.: 1-15(partially)
Remark on Protest
The additional search fees were accompanied by the applicant’s protest and, where applicable, the payment of a protest fee.
The additional search fees were accompanied by the applicant’s protest but the applicable protest fee was not paid within the time limit specified in the invitation.
No protest accompanied the payment of additional search fees.
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     G01N 33/574 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     G01N
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, BIOSIS, EMBASE

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
Y
NICOLAS JOSE LLOSA ET AL, "Immune checkpoints expression in MSI versus MSS colorectal cancers and their potential therapeutic implications", J CLIN ONCOL,Vol. 32, 01 May 2014 (2014-05-01), page 5s,
XP055273851
1-15
abstract
(2)
Y
Y. XIAO ET AL, "The Microsatellite Instable Subset of Colorectal Cancer Is a Particularly Good Candidate for Checkpoint Blockade Immunotherapy", CANCER DISCOVERY,Vol. 5, No. 1, 01 January 2015 (2015-01-01), page 16-18,
XP055271983
1-6,14,15
the whole document
(3)
Y
N. J. LLOSA ET AL, "The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints", CANCER DISCOVERY,Vol. 5, No. 1, 01 January 2015 (2015-01-01), page 43-51,
XP055349318
1-15
page 49, right-hand column, paragraph 2; figure 2
(4)
Y
NICOLASL LOSA ET AL, "The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints", JOURNAL FOR IMMUNOTHERAPY OF CANCER, BIOMED CENTRAL LTD, LONDON, UK,Vol. 3, No. 2, 04 November 2015 (2015-11-04), page 1,
XP021235584
1-15
figure 2
(5)
Y
G. BRANDACHER, "Prognostic Value of Indoleamine 2,3-Dioxygenase Expression in Colorectal Cancer: Effect on Tumor-Infiltrating T Cells", CLINICAL CANCER RESEARCH,Vol. 12, No. 4, 15 February 2006 (2006-02-15), page 1144-1151,
XP055273302
1-6
the whole document
(6)
Y
ZORAN GATALICA ET AL, "Programmed death 1 (PD-1) lymphocytes and ligand (PD-L1) in colorectal cancer and their relationship to microsatellite instability status.", J CLIN ONCOL,Vol. 32, No. 5s, 30 May 2014 (2014-05-30),
XP055199884
7-15
abstract
(7)
A
PIN WU ET AL, "PD-L1 and Survival in Solid Tumors: A Meta-Analysis", PLOS ONE,Vol. 10, No. 6, 26 June 2015 (2015-06-26), page e0131403,
XP055273298
1-15
abstract
(8)
A
NICOLÁS J LLOSA ET AL, "Immune checkpoints in MSI and CSI colorectal cancers and their translational implications", JOURNAL FOR IMMUNOTHERAPY OF CANCER, BIOMED CENTRAL LTD, LONDON, UK,Vol. 1, No. Suppl 1, 07 November 2013 (2013-11-07), page P161,
XP021167111
1-15
the whole document
(9)
A
JUNG HO KIM, "Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer", WORLD JOURNAL OF GASTROENTEROLOGY,Vol. 20, No. 15, 01 January 2014 (2014-01-01), page 4230,
XP055271940
1-15
the whole document
(10)
A
US 2015210769 A1 (FREEMAN GORDON JAMES [US] ET AL) 30 July 2015 (2015-07-30)
1-15
paragraph [0464] - paragraph [0465]
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
US 2015210769 A1
30 July 2015
AU 2015209145 A1
CA 2935423 A1
EA 201691488 A1
EP 3097121 A1
JP 2017506067 A
KR 20160110995 A
PH 12016501456 A1
SG 11201604939S A
TW 201536808 A
US 2015210769 A1
UY 35967 A
WO 2015112900 A1
07 July 2016
30 July 2015
28 February 2017
30 November 2016
02 March 2017
23 September 2016
22 August 2016
30 August 2016
01 October 2015
30 July 2015
31 August 2015
30 July 2015
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
24 February 2017
Date of mailing of the international search report:
09 May 2017
Authorized officer:
Wiesner, Martina
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