بعض محتويات هذا التطبيق غير متوفرة في الوقت الحالي.
إذا استمرت هذه الحالة ، يرجى الاتصال بنا علىتعليق وإتصال
1. (WO2017040672) PESTIVIRUS VACCINES FOR CONGENITAL TREMORS
ملاحظة: نص مبني على عمليات التَعرف الضوئي على الحروف. الرجاء إستخدام صيغ PDF لقيمتها القانونية

WHAT IS CLAIMED IS:

1. A composition comprising an inactivated pestivirus comprising a nucleic acid sequence that has at least 95% identity to SEQ ID NO: 1.

2. A composition comprising an inactivated pestivirus comprising an amino acid sequence that has at least 95% identity to SEQ ID NO: 2.

3. The composition of claim 1 or 2, wherein the pestivirus is a chemically inactivated pestivirus, and wherein the pestivirus is inactivated by treatment with an inactivating agent selected from the group consisting of binary ethyleneimine, ethyleneimine,

acetylethyleneimine, beta-ethyleneimine, beta-propiolactone, glutaraldehyde, ozone, and formaldehyde.

4. The composition of claim 1 or 2, wherein the pestivirus is a physically inactivated pestivirus, and wherein the pestivirus is inactivated by treatment with UV radiation, X-ray radiation, gamma-radiation, freeze-thawing, and/or heating.

5. The composition of claim 1 or 2, further comprising a pharmaceutically acceptable carrier and/or excipient.

6. The composition of claim 5, wherein the pharmaceutically acceptable carrier and/or excipient is an adjuvant.

7. The composition of claim 6, wherein the adjuvant is an oil-in-water emulsion-based adjuvant.

8. A composition comprising an attenuated pestivirus comprising a nucleic acid sequence that has at least 95% identity to SEQ ID NO: 1.

9. A composition comprising an attenuated pestivirus comprising an amino acid sequence that has at least 95% identity to SEQ ID NO: 2.

10. The composition of claim 8 or 9, further comprising a pharmaceutically acceptable carrier and/or excipient.

11. The composition of claim 10, wherein the pharmaceutically acceptable carrier and/or excipient is an adjuvant.

12. The composition of claim 11, wherein the adjuvant is an oil-in-water emulsion-based adjuvant.

13. The composition of claim 8 or 9, wherein the pestivirus is in freeze-dried form.

14. The composition of claim 8 or 9, wherein the composition comprises at least about 104 virus particles.

15. A composition comprising a vector comprising a nucleic acid sequence that has at least 95% identity to SEQ ID NO:3, 5, 7, 9, 11, 13, 15, 17, 19, or 21.

16. A composition comprising a vector encoding an amino acid sequence that has at least 95% identity to SEQ ID NO:4, 6, 8, 10, 12, 14, 16, 18, 20, or 22.

The composition of claim 15 or 16, wherein the vector is a baculovirus expression vector or a canine adenovirus vector.

18. A method for protecting a piglet against a disease associated with pestivirus, wherein the method comprises administering to a pregnant sow or gilt, or to a sow or gilt prior to breeding, the composition of claim 1, 2, 8, 9, 14, and/or 15, in an amount sufficient to protect the piglet.

19. The method of claim 18, wherein the disease is congenital tremor.

20. The method of claim 18, wherein the method comprises administering the composition to a pregnant sow or gilt.

21. The method of claim 18, wherein the method comprises administering the composition to a sow or gilt prior to breeding.

22. The method of claim 18, wherein the method comprises administering the composition to the sow or gilt intramuscularly.

The method of claim 18, wherein the administering is a first administration, and wherein the method further comprises a second administration one to three weeks after the first administration.