البحث في مجموعات البراءات الوطنية والدولية

1. (WO2004098496) COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS

Pub. No.:    WO/2004/098496    International Application No.:    PCT/US2004/012141
Publication Date: Fri Nov 19 00:59:59 CET 2004 International Filing Date: Wed Apr 21 01:59:59 CEST 2004
IPC: A61K 31/19
A61K 31/235
A61K 31/24
Applicants: WELLSTAT THERAPEUTICS CORPORATION
HODGE, Kirvin, L.
SHARMA, Shalini
VON BORSTEL, Reid, W.
Inventors: HODGE, Kirvin, L.
SHARMA, Shalini
VON BORSTEL, Reid, W.
Title: COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
Abstract:
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; m is 0 to 4; q is 0 or 1; t is 0 or 1; R2 is alkyl having from 1 to 3 carbon atoms; R3 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula (I) by a ring carbon; and R1 is hydrogen or alkyl having 1 or 2 carbon atoms. Alternatively, when R1 is hydrogen, the biologically active agent can be a pharmaceutically acceptable salt of the compound of Formula (I).