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1. (WO2002026696) CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS
أحدث البيانات الببلوغرافية المتوفرة لدى المكتب الدولي   

رقم النشر: WO/2002/026696 رقم الطلب الدولي: PCT/GB2001/004329
تاريخ النشر: 04.04.2002 تاريخ الإيداع الدولي: 27.09.2001
الفصل الثاني من الطلب المودع: 26.04.2002
التصنيف الدولي للبراءات:
A61K 31/16 (2006.01) ,A61K 31/195 (2006.01) ,A61K 31/198 (2006.01) ,A61K 31/277 (2006.01) ,A61K 31/38 (2006.01) ,A61K 31/381 (2006.01) ,A61K 31/426 (2006.01)
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المودعون:
WATKINS, Clare, J. [GB/GB]; GB (UsOnly)
ROMERO-MARTIN, Maria-Rosario [ES/GB]; GB (UsOnly)
MOORE, Kathryn, G. [GB/GB]; GB (UsOnly)
RITCHIE, James [GB/GB]; GB (UsOnly)
FINN, Paul, W. [GB/GB]; GB (UsOnly)
KALVINSH, Ivars [LV/LV]; LV (UsOnly)
LOZA, Einars [LV/LV]; LV (UsOnly)
STARCHENKOV, Igor; LV (UsOnly)
DIKOVSKA, Klara [LV/LV]; LV (UsOnly)
BOKALDERE, Rasma, Melita [LV/LV]; LV (UsOnly)
GAILITE, Vija [LV/LV]; LV (UsOnly)
VORONA, Maxim [LV/LV]; LV (UsOnly)
ANDRIANOV, Victor [--/LV]; LV (UsOnly)
LOLYA, Daina [LV/LV]; LV (UsOnly)
SEMENIKHINA, Valentina; LV (UsOnly)
AMOLINS, Andris [LV/LV]; LV (UsOnly)
HARRIS, C., John, [GB/GB]; GB (UsOnly)
DUFFY, James, E., S. [GB/GB]; GB (UsOnly)
PROLIFIX LIMITED [GB/GB]; 91 Milton Park Abingdon, Oxfordshire OX14 4RY, GB (AllExceptUS)
المخترعون:
WATKINS, Clare, J.; GB
ROMERO-MARTIN, Maria-Rosario; GB
MOORE, Kathryn, G.; GB
RITCHIE, James; GB
FINN, Paul, W.; GB
KALVINSH, Ivars; LV
LOZA, Einars; LV
STARCHENKOV, Igor; LV
DIKOVSKA, Klara; LV
BOKALDERE, Rasma, Melita; LV
GAILITE, Vija; LV
VORONA, Maxim; LV
ANDRIANOV, Victor; LV
LOLYA, Daina; LV
SEMENIKHINA, Valentina; LV
AMOLINS, Andris; LV
HARRIS, C., John,; GB
DUFFY, James, E., S.; GB
الوكيل:
ARMITAGE, Ian, M. ; Mewburn Ellis York House 23 Kingsway London WC2B 6HP, GB
ADRIAN H. BRASNETT and others Mewburn Ellis; York House 23 Kingsway London WC2B 6HP, GB
بيانات الأولوية:
0023985.529.09.2000GB
60/297,78514.06.2001US
العنوان (EN) CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS
(FR) COMPOSES D'ACIDE CARBAMIQUE COMPRENANT UN ENCHAINEMENT AMIDE COMME INHIBITEURS HDAC
الملخص:
(EN) This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the formula (1) wherein: A is an aryl group; Q1 is an aryl leader group having a backbone of at least 2 carbon atoms; J is an amide linkage selected from: -NR1C(=O)- and -C(=O)NR1-; R1 is an amido substituent; and, Q2 is an acid leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.
(FR) L'invention concerne certains composés d'acide carbamique actifs inhibant l'activité HDAC et correspondant à la formule (1), dans laquelle A désigne un groupe aryle ; Q1 désigne un groupe leader aryle ayant un squelette d'au moins 2 atomes de carbone; J désigne un enchaînement amide choisi à partir de: -NR1C(=O)- et-C(=O)NR1-; R1 désigne un substituant amido; et Q2 désigne un groupe leader acide ; ainsi que les sels, solvates, amides, esters, éthers pharmaceutiquement acceptables, les formes protégés chimiquement et les promédicaments de ces composés. L'invention concerne en outre des compositions pharmaceutiques comprenant de tels composés, ainsi que l'utilisation de ces composés et de ces compositions, à la fois in vitro et in vivo, en vue d'inhiber HDAC et d'inhiber, par exemple, des états de proliférations tels que cancers et psoriasis.
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الدول المعيّنة: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
المنظمة الإقليمية الأفريقية للملكية الفكرية (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
مكتب البراءات الأوروبي الآسيوي (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
المكتب الأوروبي للبراءات (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
المنظمة الأفريقية للملكية الفكرية (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
لغة النشر: الإنكليزية (EN)
لغة الإيداع: الإنكليزية (EN)