البحث في مجموعات البراءات الوطنية والدولية

1. (WO1999050249) PYRIMIDINES AND TRIAZINES AS INTEGRIN ANTAGONISTS

Pub. No.:    WO/1999/050249    International Application No.:    PCT/US1999/006827
Publication Date: Fri Oct 08 01:59:59 CEST 1999 International Filing Date: Tue Mar 30 01:59:59 CEST 1999
IPC: C07D 239/46
C07D 239/48
C07D 239/95
C07D 251/18
C07D 403/06
C07D 487/04
Applicants: DU PONT PHARMACEUTICALS COMPANY
Inventors: PITTS, William, J.
JADHAV, Prabhakar, K.
Title: PYRIMIDINES AND TRIAZINES AS INTEGRIN ANTAGONISTS
Abstract:
This invention relates to novel heterocycles which are useful as antagonists of the αvβ3 integrin, the α2bβ3 integrin, and related cell surface adhesive protein receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.