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1. (EP2655623) NON-CODING IMMUNOMODULATORY DNA CONSTRUCT
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Claims

1. A non-coding DNA construct comprising at least one sequence motif N 1N 2CGN 3N 4, wherein N 1N 2 and N 3N 4 is any combination of A, C, T, and G, and C is deoxycytidine, G is deoxyguanosine, A is deoxyadenosine and T is deoxythymidine and wherein at least one nucleotide of the terminal five nucleotides located at the 5'- and/or the 3'-end of a DNA single strand is in L-conformation.
  2. The construct according to claim 1, wherein N 1N 2 is an element selected from the group comprising GT, GG, GA, AT or AA, N 3N 4 is an element selected from the group comprising CT or TT.
  3. The construct according to any one of claims 1 or 2, wherein said DNA construct comprises at least one end with a single stranded loop.
  4. The construct according to any one of claims 1 to 3, wherein the sequence motif N 1N 2CGN 3N 4 is located within a single-stranded and/or a double-stranded region of the DNA sequence.
  5. The construct according to any one of claims 1 to 4, comprising inter- and/or intramolecular base-pairs and at least one unpaired, single-stranded region.
  6. The construct according to claim 5, wherein at least two constructs ligate with each other.
  7. The construct according to any one of claims 1 to 6, wherein at least one nucleotide in L- or D-conformation is modified with a functional group selected from the group comprising carboxyl, amine, amide, aldimine, ketal, acetal, ester, ether, disulfide, thiol and aldehyde.
  8. The construct according to claim 7, wherein the modified nucleotide is linked to a compound selected from the group comprising peptides, proteins, carbohydrates, antibodies, lipids, micelles, vesicles, synthetic molecules, polymers, micro projectiles, metal particles, nanoparticles, or a solid phase.
  9. A pharmaceutical composition comprising a DNA construct according to any one of claims 1 to 8.
  10. The pharmaceutical composition according to claim 11, comprising additionally a chemotherapeutic.
  11. A vaccine comprising a DNA construct according to any one of claims 1 to 8.
  12. The vaccine according to claim 11, wherein the DNA construct is an adjuvant.
  13. A DNA construct according to any one of claims 1 to 8, a pharmaceutical composition according to claims 9 or 10 or a vaccine according to claims 11 or 12 for use in the treatment of cancer or autoimmune diseases.