||WO||WO/2014/126534 - ANGLED-MOLD CORE ACTUATING MECHANISM||21.08.2014||
||PCT/SG2013/000062||HOONG, Heng Man||HOONG, Heng Man|
The present invention provides an angled-mold core actuator (180, 280, 380). When actuated, an angled-cavity forming core (158) is extended into a mold cavity defined by a mold insert (154). The angled-cavity forming core (158) is disposed at a 3-dimensional angle into the mold insert (154) to form a cavity (104) in a molded product. The angled-cavity forming core is actuated by a driven pin (186, 286, 386) of the angled-mold core actuator (180, 280, 380).
||WO||WO/2014/126537 - A Polymeric System for Release of an Active Agent||21.08.2014||
||PCT/SG2014/000057||AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH||KURISAWA, Motoichi|
The present disclosure relates to a polymeric system for release of an active agent, comprising a first polymeric phase containing the active agent, the first polymeric phase forming discrete regions of a set size range and being dispersed within a second polymeric phase comprising a cross-linked polymer-phenol conjugate for release of the active agent therein. The present disclosure further provides an injectable hydrogel comprising the disclosed polymeric system, a carrier for delivering a biologically active substance or a drug comprising the injectable hydrogel, and a method for producing the disclosed polymeric system.
||WO||WO/2014/126535 - A SEAFLOOR NODULE CONCENTRATING SYSTEM AND METHOD||21.08.2014||
||PCT/SG2014/000054||NAUTILUS MINERALS SINGAPORE PTE LTD||ROPER, Malcolm Leishman|
A seafloor nodule concentrating system is disclosed. The seafloor nodule concentrating system has a surface vessel and an undersea steering vehicle secured to the surface vessel. The undersea steering vehicle is adapted to be towed by the surface vessel. The seafloor nodule concentrating system also has a nodule collecting apparatus connected to the undersea steering vehicle. The nodule collecting apparatus is located on the seafloor. The seafloor nodule concentrating system also has a position determination device adapted to determine the position of the nodule collecting apparatus and communicate position information of the nodule collecting apparatus to the undersea steering vehicle and surface vessel.
||WO||WO/2014/126536 - PHOTO-RESPONSIVE MACRO- AND MICRO- LIQUID MARBLES||21.08.2014||
||PCT/SG2014/000056||AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH||CHIN, Jia Min|
The invention relates to macro- and micro-liquid marbles (i.e. droplets of liquid with a particulate-based shell), and in particular, to photo-responsive macro- and micro-liquid marbles encapsulating a substance therein. Methods for forming the macro- and micro-liquid marbles, and use of the macro- and micro-liquid marbles, in controlled release applications are also disclosed.
||WO||WO/2014/126533 - A BEARING ASSEMBLY FOR AN OFFSHORE TURRET MOORING||21.08.2014||
||PCT/SG2013/000059||PROMOR PTE LTD||HOOPER, Alan, Gregory|
A bearing assembly configured to facilitate relative rotation of a floating vessel about an uprightly disposed shaft in an offshore turret mooring provided on the vessel, the shaft having a flange disposed therearound, the bearing assembly comprising: levelling elements configured to be provided at intervals around the shaft and to engage an underside of the flange, the levelling elements being configured to distribute load among the levelling elements during angular displacement of the vessel relative to a longitudinal axis of the shaft; a bearing ring configured to be provided distanced from and around the shaft, the bearing ring having a top surface configured to engage and support the levelling elements thereon; and bearings configured to be provided distanced from and around the shaft to engage a lower surface of the bearing ring and allow rotation of the bearing ring relative to the bearings, the bearings configured to bear axial loads parallel to a longitudinal axis of the shaft, the bearings further configured to be secured to a supporting structure provided on the vessel.
||WO||WO/2014/123484 - Methods For Reducing Aggregate Content In Protein Preparations||14.08.2014||
||PCT/SG2014/000046||AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH||GAGNON, Peter Stanley|
A method of reducing aggregate and product-contaminant complex content in a protein preparation including a desired protein includes (i) contacting the protein preparation with at least one solid surface comprising at least one surface-bound ligand capable of binding a metal, the surface-bound ligand being capable of binding a metal is initially substantially devoid of a metal, the operating conditions are selected to substantially prevent the binding of the desired protein to the at least one solid surface and (ii) separating the protein preparation from the surface-bound ligand, such that when more than one surface- bound ligand is present, each surface-bound ligand is independently either of the same net charge or charge neutral.
||WO||WO/2014/123485 - PROTEIN PURIFICATION METHODS||14.08.2014||
||PCT/SG2014/000047||AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH||GAGNON, Peter Stanley|
A method for the purification of a desired protein from a protein preparation includes conditioning the protein preparation by treatment with soluble organic multivalent ions, immobilized organic multivalent ions, or both, optionally in the presence of supersaturated allantoin, thereby removing at least 90% of chromatin, then (1) precipitating the desired protein with a non-ionic organic polymer in the presence of non-protein-precipitating salts at greater than physiological concentration to provide a precipitate of the desired protein; or (2) precipitating the desired protein with a nonionic organic polymer in the absence of non-precipitating salts at greater than physiological concentration to provide a precipitate and subsequently washing the precipitate with a nonionic organic polymer in the presence of non-protein-precipitating salts at greater than physiological concentration.
||WO||WO/2014/123483 - MIXED MULTIFUNCTIONAL METAL AFFINITY SURFACES FOR REDUCING AGGREGATE CONTENT IN PROTEIN PREPARATIONS||14.08.2014||
||PCT/SG2014/000045||AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH||GAGNON, Peter Stanley|
A composition for reducing the aggregate content of a protein preparation includes a first substrate having a first surface-bound ligand possessing a metal affinity functionality, the metal affinity functionality being substantially devoid of a metal, and an additional surface-bound ligand different from the first surface-bound ligand, the additional surface-bound ligand having an aggregate charge not opposite to that of the metal affinity functionality, optionally the additional surface-bound ligand is provided on an additional substrate such that the composition comprises a mixture of the first substrate and the additional substrate.
||WO||WO/2014/123486 - METHODS FOR REDUCING AGGREGATE LEVELS IN PROTEIN PREPARATIONS BY TREATMENT WITH THIO-HETEROCYCLIC CATIONS||14.08.2014||
||PCT/SG2014/000048||AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH||GAGNON, Peter Stanley|
A method of reducing the aggregate content in a protein preparation having a target protein includes contacting the protein preparation with a thio-heterocyclic cation to form a mixture, contacting the mixture with at least one functionalized solid to remove excess thio-heterocyclic cations; and optionally contacting the mixture, simultaneously or sequentially, with at least one further functionalized solid to further reduce aggregate content of the protein preparation.
||WO||WO/2014/123488 - ELECTRO-OPTIC CERAMIC MATERIALS||14.08.2014||
||PCT/SG2014/000050||AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH||SHANNIGRAHI, Santiranjan|
The present invention provides a product and manufacturing method for electro-optic ceramic material having the composition (A'(1-y)A"y)1-XLnxM(1-2X/5)O3 wherein 0 < x < 0.1; 0 < y < 1; A' and A" are independently, alkali metals; Ln is a lanthanide metal; and M is a transition metal. The present invention provides a product and manufacturing method for an electro-optic device that is operable at room temperature and the properties of which are tunable by an applied external electric field.