|1.||WO||WO/2014/121764 - 2-SUBSTITUTED-6-BIARYLMETHYLAMINO-9-CYCLOPENTYL-9H-PURINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS||14.08.2014||
||PCT/CZ2014/000014||UNIVERZITA PALACKEHO V OLOMOUCI||GUCKY, Tomas|
This invention relates to novel 2-substituted-6-biarylmethylamino-9-cyclopentyl-9H-purine derivatives, showing activity as specific inhibitors of growth and angiogenesis of hepatocellular carcinoma. The invention further includes pharmaceutical compositions containing the 2-substituted-6-biarylmethylamino-9-cyclopentylpurines.
|2.||WO||WO/2014/121763 - EQUIPMENT TO IDENTIFY UNDERSIRABLE OBJECTS IN CAVITIES||14.08.2014||
|PCT/CZ2013/000010||UNIVERZITA J.E.PURKYNĚ V ÚSTÍ NAD LABEM||MÁDL, Jan|
A equipment to identify undesirable objects, in particular after machining, comprising a body (1), to which a spring-loaded element (2) is attached and there is a contact with sound and/or light alarm between the body (1) and the spring-loaded element (2). The device can be placed in the tool tray on the machine tool.
|3.||WO||WO/2014/117754 - EQUIPMENT FOR LOADING SURFACE LAYER OF MATERIAL||07.08.2014||
|PCT/CZ2013/000007||UNIVERZITA J.E.PURKYNĚ V ÚSTÍ NAD LABEM||HOLEŠOVSKÝ, František|
Equipment for loading for loading he surface layer of material consists of the bed (1) with an electric motor (2) with a drive spindle (3) provided with a carrier (4) and a clamping point (5) for holding the test specimen rotation (6) and roller (7) seated against the perimeter of the rotary test sample (6). Roller (7) is provided with a loading element (8) to the pressing surface of the rotary test sample (6). Electric motor (2) is fitted with a frequency converter for infinitely variable speed. The equipment can be used to monitor changes in surface loads in corrosive environments.
|4.||WO||WO/2014/117756 - PISTON MACHINE WITH ADIABATIC EXPANSION SPACE||07.08.2014||
|PCT/CZ2014/000013||KORČIŠ, Vavřinec||KORČIŠ, Vavřinec|
The piston machine with adiabatic expansion space has an expansion space (8) in which there occurs the adiabatic thermodynamic action, when there occurs thermal exchange between the operation medium and the surrounding environment only in negligible volume, which means an increase of the piston machine efficiency. The base of the machine is the set (1) of the cylinder, the complex piston (3) with gudgeon pin (4) for connection of the piston (3) with the piston rod (5) and crank shaft (6) in the case (11). The complex piston (3) consists of the carrier (7), the piston (9) and the guide ring (10). The set (1) of the cylinder consists of the bushing (12) and the cylinder (14). The bushing (12) and the guide ring (10) create the set for straight guide of the piston (9) in the cylinder (14) and for absorption of side pressures between them. The expansion space (8), consisting of the bottom (20) of the piston (9) and inner surface (19) of the cylinder (14), is separated from the bushing (12) and the guide ring (10) by thermal insulation (16). The movement of the guide ring (10) on the walls of the bushing (12) is supported by the lubricant which is not subject to degradation by influence of heat or chemical influence of the medium. When there is flexibly placed the cylinder (14) and the piston (9) and there is selected the suitable material, a freely aligned set is developed in the expansion space (8) where tightness is reached without piston rings and where no cooling or lubrication is needed due to absence of side pressures and impacts.
|5.||WO||WO/2014/117755 - ANTIBIOTIC PREPARATION AND USE THEREOF||07.08.2014||
|PCT/CZ2014/000010||UNIVERZITA PALACKEHO V OLOMOUCI||PANACEK, Ales|
The invention provides a preparation containing an antibiotic, with the exclusion of β-lactam antibiotics, and silver in the form selected from nano- or microparticles and silver compound, for use in the treatment of infections caused by bacteria resistant against the antibiotic. It further provides use of this preparation for the treatment of surfaces and/or material against resistant bacteria. The invention further includes an antibiotic preparation containing a mixture of an antibiotic, with the exclusion of β-lactam antibiotics, and silver nano- or microparticles, without a chemical bond between the antibiotic and silver. The present preparations are useful in particular in human or veterinary medicine, medical tools and materials, or in cosmetics to eliminate bacterial infections caused by classical antibiotic-resistant bacteria. ˙
|6.||WO||WO/2014/114276 - A METHOD OF GRINDING WORKPIECES OF ALUMINUM ALLOY TO ACHIEVE A HIGH SURFACE QUALITY||31.07.2014||
|PCT/CZ2014/000011||UNIVERZITA J. E. PURKYNE V USTI NAD LABEM||NOVAK, Martin|
A method of grinding workpieces of aluminium alloys to achieve high surface quality, where the workpiece is machined in an environment comprising a semi-synthetic liquid with a concentration of 3 to 7%, by a grinding wheel with the grain of green silicon carbide of a size smaller than 200μm, in a bonding agent consisting of synthetic resin, at a circumferential speed of the workpiece in the range of 20 to 30 m-min-1, where the cutting speed of the grinding wheel is in the range of 35 to 40 m.s-1, the radial feed rate during plunge grinding is between 0.07 to 0.13 mm-min-1 or the longitudinal axial feed raters between 0.01 to 0.04 m.min-1.
|7.||WO||WO/2014/111064 - METHOD OF MANIPULATION WITH SAMPLES OF BIOLOGICAL MATERIAL AND A DEVICE FOR SUCH MANIPULATION||24.07.2014||
|PCT/CZ2013/000005||WOLF & DANNIEL S.R.O.||WOLF, Jan|
Method of manipulation with samples of biological material, especially for molecular diagnostics or for isolation of nucleic acids and from them possible consequent detection of a certain genome, for example a pathogenic one, and/or diagnostics of genetically determined diseases of living organisms. The sample of biological material at the beginning of the process is inserted into the loading chamber (11) of the device for manipulation with samples of biological material, into whose storage chambers (12) all reagent chemicals necessary for the respective process separately one from another were deposited still before, while the following phases of the process are running inside the device without a direct manipulation of operating person with reagent chemicals, which are gradually mixed and react, at the same time the unwilling residues from reactions are deposited into the waste chamber (41), which is also situated inside the manipulation device and it is safely separated from other areas of the device, operating persons as well as environment.
|8.||WO||WO/2014/111068 - A SOUND ABSORBING MEANS CONTAINING AT LEAST ONE CAVITY RESONATOR||24.07.2014||
|PCT/CZ2014/000008||TECHNICKA UNIVERZITA V LIBERCI||KALINOVA, Klara|
The invention relates to a sound absorbing means containing at least one cavity resonator, on whose at least one surface is fixedly attached a resonant membrane (5), which overlaps an orifice /orifices (41) leading into the cavity/cavities (1 ) of the cavity resonator.
|9.||WO||WO/2014/111069 - HELQUAT DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF AS MEDICAMENTS||24.07.2014||
|PCT/CZ2014/000009||USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR, V.V.I.||TEPLY, Filip|
The invention provides helquat derivatives of general formula I, wherein substituents R1 and R2 are independently selected from a group comprising H and C1 to C3 alkyl; up to three of S1,2, S1',2', S3,4 and S3',4' are present, each of S1,2, S1',2', S3,4 and S3',4' independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms; one or two atoms selected from the carbon atoms with the descriptor 2, 4, 2', and 4' are substituted with a substituent R3 of general formula (II) or general formula (III) wherein R4 is substituted or unsubstituted aryl; T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms; and anions (X1)- and (X2)- independently represent anions of pharmaceutically acceptable salts. The helquat derivatives are useful as medicaments in the treatment of diseases related to increased cellular proliferation, such as oncologic diseases. ˙
|10.||WO||WO/2014/111067 - A SOUND ABSORPTIVE ELEMENT COMPRISING AT LEAST ONE ACOUSTIC RESONANCE MEMBRANE FORMED BY A LAYER OF POLYMERIC NANOFIBERS||24.07.2014||
|PCT/CZ2014/000007||TECHNICKA UNIVERZITA V LIBERCI||KALINOVA, Klara|
The invention relates to a sound absorbing means which comprises at least one acoustic resonance membrane (1) formed by a layer of polymeric nanofibers which is fixedly attached to a frame (2, 20).