Oral pharmaceutical dosage form comprising tromethamine and a NSAID selected from the group comprising ibuprofen, naproxen and flurbiprofen, characterized in that it also comprises a compound selected from the group comprising glycine, vitamine B6 and mixtures thereof.

The novel active ingredient combinations made of a carboxamide of general formula (I) (group 1) (I) wherein A, R1 and R2 have the meaning cited in the description, and active ingredient groups (2) (24) which are disclosed in the description, have excellent fungicidal characteristics.

This invention relates to methods for treating or preventing hepatitis C virus infections in mammals using Toll-Like Receptor (TLR)7 ligands and prodrugs thereof. More particularly, this invention relates to methods of orally administering a therapeutically effective amount of one or more prodrugs of TLR7 ligands for the treatment or prevention of hepatitis C viral infection. Oral administration of these TLR7 immunomodulating ligands and prodrugs thereof to a mammal provides therapeutically effective amounts and reduced undesirable side effects.

A device for initiating an electric detonator utilizing an open circuit to decrease occurrences of accidental detonation. The device may include an initiator housing (12), at least two conductor pins (14) disposed through the initiator housing and spaced within the housing such that they are electrically isolated from one another, and a primer spot material (16) disposed between the conductor pins. The primer spot material may be comprised of a mixture of reactive material and metal component. The primer spot material has electrical properties which provide resistance to conducting an electrical current to maintain an open circuit condition prior to occurrence of a breakdown voltage which is dependent upon the amount of metal component in the primer spot material. Subsequently, the primer spot material has electrical properties which provide a conductive medium on the occurrence of an electrical arc between the conductive pins that arises at voltages in excess of the breakdown voltage. Finally, the electrical properties are such that the electrical arc provides energy to form a plasma from the primer spot material, leading to initiation of the detonator.

The invention relates to producing and processing liquid metal in metallurgy. The inventive tuyere device for introducing gaseous media under a liquid-metal layer comprises a refractory nest block provided with a sleeve incorporated therein, coaxial metal tubes provided with at least one central operating channel and at least one annular operating channel which are arranged on the side thereof for entering a liquid metal and separately connected to inlets for supplying gaseous media to the metal. According to said invention, said coaxial metal tubes consist of two interconnected sections having different diameters. The first section has a smaller diameter and is used for supplying the gaseous media to the liquid metal. The second section has a larger diameter and is connected to said inlets for separately supplying the gaseous media to the operating channels of the first section. The second section is provided with an additional tube and with the annular operating channels only. The internal tube of said section is closed on the both ends thereof and filled with a refractory material, the spaces of said annular operating channels of the tuyere are embodied in the form of capillaries for the liquid metal. Said invention makes it possible to exclude a metal break through the operating channels.

An indazole having analgesic activity, a method for the preparation thereof and a pharmaceutical composition containing the same; the indazole has the following general formula: where X, Ra, Rb, Rc and Rd have the meanings stated in the description.

A lock (10) that includes a wedge (12) and spool (14) are used to releasably secure separable components of an assembly together. The wedge (12) and spool (14) are threadedly coupled together to drive the wedge into and out of an opening in the assembly without hammering or prying. The direct coupling of the wedge (12) and spool eliminates the need for bolts, washers, nuts and other hardware so as to minimize the number of parts. As a result, the lock is inexpensive to make, easy to use, and unlikely to become inoperative because of lost or broken parts or due to fines or other difficulties encountered in harsh digging environments. Further, the wedge (12) can be driven into the assembly to provide the degree of tightness necessary for the intended operation and/or to re-tighten the assembly after incurring wear during use. A latch assembly (56) is preferably provided to securely hold the wedge (12) in place and avoid and undesired loss of parts during use.

The invention relates to granulating solid products, in particular mineral fertilisers using liquid and solid initial products. The inventive drum granulator comprises a main drum provided with a transport attachment embodied in the form of distribution blades which are arranged in several ranges on the internal surface thereof and in form of retaining blades which are arranged prior to said distribution blades and a retaining ring on the output end of the drum. Said drum granulator also comprises an additional external drum, a reverse conveyor worm which is arranged between the drums and rotates therewith, a product loading chamber embodied in the form of an external ring provided with receiving-transporting blades which are arranged oppositely with respect to the reception windows of the main drum, conveying chutes arranged after each reception window, a screw conveyor placed between the loading chamber and the retaining blades, a product unloading chamber, a device for returning a fine fraction to the main drum disposed in the annular space between drums after the reverse conveyor worm, a nozzle and a loading tube mounted on the fixed part of the loading chamber. The main drum comprises a classifier connected to two drums and a classifier cleaner fixed to the wall of the unloading chamber. The device for returning the fine fraction is embodied in the form of radial receiving-distributing-transporting blades which pass through the reception windows to the main drum and is disposed between the retaining and distribution blades. Said invention makes it possible to ensure a uniform circulation of the fine fraction and the mixing of components.

The method is referred to hydrometallurgical process and serves for recovery of nonferrous, rare and precious metals from sulfide minerals and concentrates. The invention is aimed at creating conditions for the most complete extraction of metals, preventing formation of elementary sulfur. The objective is attained by means of the following: the hydrometallurgical method of sulfide minerals and concentrates processing, which involves sulfide minerals oxidation in aqueous medium using nitrogen oxides, envisages that the sulfide materials containing slurry are subjected to oxidation of the sulfide and the oxidation is realized under controlled conditions of the slurry acidity, i.e. with constant neutralization of sulfuric acid formed as a result of the sulfides oxidation, moreover, sulfuric acid is neutralized to acidity level, at which no formation of elementary sulfur occurs, while natural or artificial substances, such as CaC03, MgC03, Ca(OH)2, CaO, NaOH, CaHP04 etc., are used as acidity neutralizers; the choice of a specific neutralizer is dictated by the necessity of formation of slurry neutralization products with assigned physicochemical properties: filterability, slurry thickening, arsenic substance insolubility, non­toxicity and other required properties. Oxidation of sulfide minerals is realized under agitation providing sufficient mass exchange and efficient occurrence of chemical reactions. Oxidation is realized in the temperature range of 20-90°C, mainly in the range of 65-85°C. The liquid-to-solid ratio may vary from 1:1 to 5:1, depending on effectiveness of the required precipitate formation and proceeding of sulfide oxidation reactions. Nitric and nitrous acids, as well as their oxides, mainly nitrous acid, HN02, and its oxide, N203, are used as oxidizing agents. Regeneration processes of NO to N203 are also described.

The method is referred to hydrometallurgy process and it serves for recovery of nonferrous, rare and precious metals from robust (hard to process) minerals, which may contain natural carbon or other robust compounds. This invention is aimed at increasing the recovery of nonferrous, rare and precious metals from robust minerals with simultaneous reduction of processing costs. The objective is attained, as the method for recovery of nonferrous, rare and precious metals from robust minerals envisages the processing of robust carbon-containing minerals by oxygen-containing oxidant with subsequent extraction of precious metal compounds from liquid phase, moreover, the treatment of robust carbon-containing minerals by oxygen-containing oxidant is performed in the presence of reducing agents featuring donor-acceptor properties, which are manifested in the fact that at the first stage of chemical reactions the reducing agents give their electrons to oxygen-containing oxidant and, as a result, form a stronger oxidant than the initial one, in the from of short-lived radicals and intermediate oxidation products of donor-acceptor reducing agents, which are oxidants, as well.