The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient. The present invention provides a process of producing said crystalline composition or pharmaceutical composition. The present invention also provides compositions with a specific particle size distribution.

The present invention relates to compounds having the structure Formula (I) useful as potassium channel inhibitors to treat cardiac arrhythmias.

A hands-free personal communication device is worn about a user's neck. The communication device includes an elongated elastic neckband for supporting the communication device about the user's neck. The elastic neckband has memory characteristic and is bendable along its length such that the neckband is formable into and out of various selectable positions. An acoustic output device is attached to the neckband and positioned near an ear of the user when the communication device is worn about the user's neck. A microphone is attached to an end of the neckband. A detachable earbud may be attached to an end of the neckband.

La presente invención se encuentra dentro del sector de la ingeniería mecánica y materiales y trata sobre un sistema auto ajustable de rieles con travesia con características múltiples que extienden la vida útil del sistema de travesía en un factor mínimo de cuatro, mientras proveen un respaldo de seguridad al proveer redundancia al sistema de líneas, permitiendo a los pasajeros humanos moverse de una ubicación a otra ubicación, en forma fácil y segura, con un mínimo de ruido y vibración, mientras brindan al dueño del sistema los beneficios de menores costos de mantenimiento y menor exposición al riesgo financiero. También El sistema puede ser instalado en una multitud de lugares naturales variedades sin necesidad de cortar o dañar el ambiente. Usando las mismas componentes este sistema ofrecen otras opciones de configuración para ampliar las posibilidades de brindar una sistema con características conducente a una multitud de inclinaciones. Combinando los varios componentes empezando con un riel lisa como Fig.1 con el sistema auto Igualar Fig.3 para máximo conservacíon de energía, hacia maximo freno cor riel esqueleto en Fig. 2 con el sistema de seguridad de alto freno Fig.4

A method for incorporating instrumentation in determining sensory quality of citrus pulp in citrus juice by measuring, using image-based measurements, one or more parameters of the pulp in a sample of the citrus juice, linking the parameter measurements to sensory evaluations, and making a sensory determination of the quality of the pulp content in the juice, which is linked to consumers acceptance of the amount of pulp in the juice is disclosed.

This invention relates to methods for treating or preventing hepatitis C virus infections in mammals using Toll-Like Receptor (TLR)7 ligands and prodrugs thereof. More particularly, this invention relates to methods of orally administering a therapeutically effective amount of one or more prodrugs of TLR7 ligands for the treatment or prevention of hepatitis C viral infection. Oral administration of these TLR7 immunomodulating ligands and prodrugs thereof to a mammal provides therapeutically effective amounts and reduced undesirable side effects.

Substituted heteroaryl fused pyridine, pyrazine, and pyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

The present invention relates generally to the field of data migration and conversion from any source of data. More particularly, the present invention relates to the field of converting heterogeneous data to a user-defined format. For the purpose of sharing data, analyzing and deriving intelligent information from converted data. The present invention enables the features of relational database technologies to be used on non-relational database generated data without programming effort.

Recombinant polypeptides are disclosed that are useful for diagnosing American trypanosomiasis, or Chagas disease, a disease caused by the infectious agent Trypanosoma cruzi. Preferably, DNA sequences encoding the recombinant proteins are placed in plasmid vectors to be expressed in an organism.

The present invention is directed to a pharmaceutically acceptable taste masking liquid excipient base for administration of a relatively large amount of unpleasant tasting medicines. More particularly, the enhanced sweetness and taste masking effect are produced by the addition of sucralose to the excipient base with maintenance of a pH from about 2 to about 5. The invention is further directed to medicinal compositions comprising such a liquid excipient base and unpleasant tasting medicines. Still further, the invention is directed to a method for taste masking unpleasant tasting medicines through their incorporation into the claimed liquid excipient bases.