||WO||WO/2014/123484 - Methods For Reducing Aggregate Content In Protein Preparations||14.08.2014||
||PCT/SG2014/000046||AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH||GAGNON, Peter Stanley|
A method of reducing aggregate and product-contaminant complex content in a protein preparation including a desired protein includes (i) contacting the protein preparation with at least one solid surface comprising at least one surface-bound ligand capable of binding a metal, the surface-bound ligand being capable of binding a metal is initially substantially devoid of a metal, the operating conditions are selected to substantially prevent the binding of the desired protein to the at least one solid surface and (ii) separating the protein preparation from the surface-bound ligand, such that when more than one surface- bound ligand is present, each surface-bound ligand is independently either of the same net charge or charge neutral.
||WO||WO/2014/123485 - PROTEIN PURIFICATION METHODS||14.08.2014||
||PCT/SG2014/000047||AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH||GAGNON, Peter Stanley|
A method for the purification of a desired protein from a protein preparation includes conditioning the protein preparation by treatment with soluble organic multivalent ions, immobilized organic multivalent ions, or both, optionally in the presence of supersaturated allantoin, thereby removing at least 90% of chromatin, then (1) precipitating the desired protein with a non-ionic organic polymer in the presence of non-protein-precipitating salts at greater than physiological concentration to provide a precipitate of the desired protein; or (2) precipitating the desired protein with a nonionic organic polymer in the absence of non-precipitating salts at greater than physiological concentration to provide a precipitate and subsequently washing the precipitate with a nonionic organic polymer in the presence of non-protein-precipitating salts at greater than physiological concentration.
||WO||WO/2014/123483 - MIXED MULTIFUNCTIONAL METAL AFFINITY SURFACES FOR REDUCING AGGREGATE CONTENT IN PROTEIN PREPARATIONS||14.08.2014||
||PCT/SG2014/000045||AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH||GAGNON, Peter Stanley|
A composition for reducing the aggregate content of a protein preparation includes a first substrate having a first surface-bound ligand possessing a metal affinity functionality, the metal affinity functionality being substantially devoid of a metal, and an additional surface-bound ligand different from the first surface-bound ligand, the additional surface-bound ligand having an aggregate charge not opposite to that of the metal affinity functionality, optionally the additional surface-bound ligand is provided on an additional substrate such that the composition comprises a mixture of the first substrate and the additional substrate.
||WO||WO/2014/123486 - METHODS FOR REDUCING AGGREGATE LEVELS IN PROTEIN PREPARATIONS BY TREATMENT WITH THIO-HETEROCYCLIC CATIONS||14.08.2014||
||PCT/SG2014/000048||AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH||GAGNON, Peter Stanley|
A method of reducing the aggregate content in a protein preparation having a target protein includes contacting the protein preparation with a thio-heterocyclic cation to form a mixture, contacting the mixture with at least one functionalized solid to remove excess thio-heterocyclic cations; and optionally contacting the mixture, simultaneously or sequentially, with at least one further functionalized solid to further reduce aggregate content of the protein preparation.
||WO||WO/2014/123488 - ELECTRO-OPTIC CERAMIC MATERIALS||14.08.2014||
||PCT/SG2014/000050||AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH||SHANNIGRAHI, Santiranjan|
The present invention provides a product and manufacturing method for electro-optic ceramic material having the composition (A'(1-y)A"y)1-XLnxM(1-2X/5)O3 wherein 0 < x < 0.1; 0 < y < 1; A' and A" are independently, alkali metals; Ln is a lanthanide metal; and M is a transition metal. The present invention provides a product and manufacturing method for an electro-optic device that is operable at room temperature and the properties of which are tunable by an applied external electric field.
||WO||WO/2014/123487 - METHODS FOR TESTING A BATTERY AND DEVICES CONFIGURED TO TEST A BATTERY||14.08.2014||
||PCT/SG2014/000049||NANYANG TECHNOLOGICAL UNIVERSITY||YAZAMI, Rachid|
According to various embodiments, a method for testing a battery may be provided. The method may include: bringing the battery to a pre-determined voltage; determining a parameter of the battery, the parameter of the battery comprising at least one of an entropy of the battery at the pre-determined voltage or an enthalpy of the battery at the pre-determined voltage; and determining an ageing history of the battery based on the determined parameter.
||WO||WO/2014/120082 - A PLANAR POSITIONING SYSTEM AND METHOD OF USING THE SAME||07.08.2014||
||PCT/SG2013/000039||AKRIBIS SYSTEMS PTE LTD||BUDIMAN, Sastra|
A positioning system having a flat base comprising (i) a X-axis assembly having a X-axis linear actuator means arranged orthogonal to the Y-axis; (ii) a Y-axis assembly having a pair of Y-axis linear actuator means mounted onto the flat base forming a H-configuration; (iii) a Z-axis assembly having an aerostatic bearing mechanism that floats on thin film of externally pressurized air on top of the flat base; and a θ-axis actuator anchored from the X-axis to drive the Z-axis assembly which carries a workpiece, wherein the Z-axis assembly is rotated with the rotary axis for the θ-axis perpendicular to the flat base.
||WO||WO/2014/120081 - A STEM FOR A GATE VALVE||07.08.2014||
||PCT/SG2013/000037||AKER SOLUTIONS SINGAPORE PTE LTD||KUSWANTORO, Eko|
A stem for a gate valve, a gate valve, a method of assembling a stem in a gate valve, a method of fabricating the stem, and a method of assembling a gate valve are provided. The stem comprises a rotatable first stem section; and a rotatable second stem section separable from the first stem section and configured to engage with a gate of the gate valve for moving the gate between closed and open positions; wherein, in a disengaged state, the first stem section is rotatably free from the second stem section, and wherein, in an engaged state, the first stem section is rotatably coupled to the second stem section such that the second stem section is rotatable together with the first stem section for moving the gate between the closed and open positions.
||WO||WO/2014/120083 - MINIATURIZED XENON FLASH MODULE||07.08.2014||
||PCT/SG2013/000041||XENON TECHNOLOGIES PTE LTD||KIM, Young Chung|
A xenon flash module for use in an image capturing device which comprises a lens housing. The lens housing has a protruding portion that forms a lens window. The lens housing and the lens window define an interior, and the interior comprises a reflector arranged adjacent to a xenon lamp. The interior also comprises a reflector cover that substantially encapsulates the reflector; and a plurality of electronic components mounted on a printed circuit board. Wherein the lens window has a recess, and the recess is adapted to receive a portion of the reflector, and the reflector is arranged such that the portion of the reflector extends into the recess.
||WO||WO/2014/120080 - LNG CARRIER CONSTRUCTION METHOD||07.08.2014||
||PCT/SG2013/000036||KEPPEL OFFSHORE & MARINE TECHNOLOGY CENTRE PTE LTD||NEDUMARAN, Asok Kumar|
A structural block is fabricated with necessary components and structure for LNG storage and/or process. The structural block may be an LNG tank with the same configuration as that in an LNG carrier. The structural bock may also be a regasification plant or a liquefaction plant to be used for LNG process. An existing vessel, e.g. an LNG carrier, is cut apart to form a forward section and a aft section. The forward section and the aft section are moved away from each other to form a space therebetween. The structural block is then placed into the space and jointed to the forward and aft sections, by welding for example, to form an integrated new vessel. The structural block provides the new vessel with increased LNG storage and transportation capabilities as well as regasification and/or liquefaction process facilities to meet the increased demand for LNG storage, transportation and processing.