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No | Ctr | Title | PubDate | Int.Class | Appl.No | Applicant | Inventor | ||||
| 1. | US | 20090041717 - High affinity human antibodies to human nerve growth factor | 12.02.2009 |
| 12188330 | Regeneron Pharmaceuticals, Inc. | MacDonald Lynn | ||||
A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis. | |||||||||||
| 2. | US | 20110256587 - High affinity human antibodies to human nerve growth factor | 20.10.2011 |
| 13166905 | Regeneron Pharmaceuticals, Inc. | Macdonald Lynn | ||||
A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis. | |||||||||||
| 3. | US | 20120164688 - HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR | 28.06.2012 |
| 13406734 | MACDONALD Lynn | MACDONALD Lynn | ||||
A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis. | |||||||||||
| 4. | EP | 2572729 - High affinity human antibodies to human nerve growth factor | 27.03.2013 |
| 12198210 | REGENERON PHARMA | REINHARDT JOEL C | ||||
A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with K D of 5 pM or less and does not cross-react with neurotrophin-3 (NT-3). The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from bums, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.
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| 5. | WO | WO/2009/023540 - HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR | 19.02.2009 |
| PCT/US2008/072561 | REGENERON PHARMACEUTICALS, INC. | MACDONALD, Lynn | ||||
A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, does not cross-react with neurotrophin-3 (NT-3), and binds human NGF with a KD of about 2 to about 10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from bums, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.
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| 6. | EP | 1181318 - MONOCLONAL ANTIBODIES, SYNTHETIC AND BIOTECHNOLOGICAL DERIVATIVES THEREOF ACTING AS NGF-ANTAGONIST MOLECULES | 27.02.2002 |
| 00935482 | LAY LINE GENOMICS SPA | NOVAK MICHAL M | ||||
Monoclonal antibodies, synthetic and biotechnological derivatives thereof (ScFv or others) are able to recognise the NGF high affinity receptor, TrkA, and act as NGF-antagonist molecules. Pharmacological compositions for therapy, gene therapy, diagnostics of neurological pathologies are also described. Transgenic animal models to study such pathologies are also described.
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| 7. | WO | WO/2000/073344 - MONOCLONAL ANTIBODIES, SYNTHETIC AND BIOTECHNOLOGICAL DERIVATIVES THEREOF ACTING AS NGF-ANTAGONIST MOLECULES | 07.12.2000 |
| PCT/IT2000/000218 | LAY LINE GENOMICS SpA | NOVAK, Michal, M. | ||||
Monoclonal antibodies, synthetic and biotechnological derivatives thereof (ScFv or others) are able to recognise the NGF high affinity receptor, TrkA, and act as NGF-antagonist molecules. Pharmacological compositions for therapy, gene therapy, diagnostics of neurological pathologies are also described. Transgenic animal models to study such pathologies are also described.
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| 8. | KR | 1020100058537 - HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR | 03.06.2010 |
| 1020107005181 | REGENERON PHARMACEUTICALS, INC. | MACDONALD LYNN | ||||
A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, does not cross-react with neurotrophin-3 (NT-3), and binds human NGF with a KD of about 2 to about 10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from bums, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis. COPYRIGHT KIPO WIPO 2010
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| 9. | MX | MX/a/2010/001395 - HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR | 17.05.2010 |
| MX/a/2010/001395 | REGENERON PHARMACEUTICALS, INC | JOEL H. MARTIN | ||||
A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, does not cross-react with neurotrophin-3 (NT-3), and binds human NGF with a KD of about 2 to about 10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from bums, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.
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| 10. | SG | 159029 - HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR | 30.03.2010 |
| 2010007854 | REGENERON PHARMACEUTICALS, INC | MACDONALD, LYNN | ||||
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